Journal
Nature
Publication Date
6-1-2022
Volume
606
Issue
7913
First Page
343
Last Page
350
Document Type
Open Access Publication
DOI
10.1038/s41586-022-04786-y
Rights and Permissions
Mitchell, E., Spencer Chapman, M., Williams, N. et al. Clonal dynamics of haematopoiesis across the human lifespan. Nature 606, 343–350 (2022). https://doi.org/10.1038/s41586-022-04786-y This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Recommended Citation
Mitchell, Emily; Spencer, David H; and et al, "Clonal dynamics of haematopoiesis across the human lifespan." Nature. 606, 7913. 343 - 350. (2022).
https://digitalcommons.wustl.edu/open_access_pubs/12029
Supplementary Information
41586_2022_4786_MOESM2_ESM.pdf (2749 kB)
Reporting Summary
41586_2022_4786_MOESM3_ESM.pdf (1996 kB)
Peer Review File
41586_2022_4786_MOESM4_ESM.zip (81549 kB)
Supplementary Data - HTMLs of notebooks outlining key statistical analyses presented in the manuscript, including analysis of phylogenetic trees
41586_2022_4786_MOESM5_ESM.xlsx (9 kB)
Supplementary Table 1 - Demographic data and clinical details for donors used in the study
41586_2022_4786_MOESM6_ESM.xlsx (9 kB)
Supplementary Table 2 - Details of antibodies used for flow cytometry in the study
41586_2022_4786_MOESM7_ESM.xlsx (35 kB)
Supplementary Table 3 - Structural variants observed in the dataset
41586_2022_4786_MOESM8_ESM.xlsx (19 kB)
Supplementary Table 4 - Genes used as known clonal haematopoiesis, myeloid malignancy genes or cancer genes
41586_2022_4786_MOESM9_ESM.xlsx (29 kB)
Supplementary Table 5 - Variants identified in known myeloid genes in the dataset
41586_2022_4786_MOESM10_ESM.xlsx (205 kB)
Supplementary Table 6 - Results of dNdScv analysis for the top 1500 genes with most significant mutation burdens
41586_2022_4786_MOESM11_ESM.xlsx (3273 kB)
Supplementary Table 7 - Coding variants observed in the study
41586_2022_4786_MOESM12_ESM.xlsx (10 kB)
Supplementary Table 8 - Variants observed in ZNF318 and HIST2H3D in our dataset
41586_2022_4786_MOESM13_ESM.xlsx (11 kB)
Supplementary Table 9 - Variants in ZNF318 and HIST2H3D seen in 534 AML genomes
