DOI

10.1186/s13024-016-0073-8

Document Type

Open Access Publication

Journal

Molecular Neurodegeneration

Volume

11

Inclusive Pages

9

Publication Date

2016

s13024-016-0073-8-s1.docx (20 kB)
Heparin sulfate proteoglycan (HSPG) primer pairs for quantitative polymerase chain reaction (qPCR)

Supp2.jpeg (28 kB)
Soluble, monomeric Aβ 1-40 induces lipid oxidation in human VSMC

Supp3.jpeg (31 kB)
Apocynin does not impact baseline ROS production in VSMC

Supp4.jpeg (70 kB)
HSPG mitigates Aβ 1-40 -induced mitochondrial and cytosolic ROS production in VSMC under physiological oxygen concentration

Supp5.jpeg (75 kB)
Aβ 1-40 and Aβ 1-42 remain mostly in soluble, monomeric form after 30 minute incubation in L-15 media

Supp6.jpeg (90 kB)
HSPG subtype mRNA is present in primary human cerebral and transformed rat cerebral VSMC

Supp7.jpeg (42 kB)
Human VSMC cells from second source conform that HSPG mitigates Aβ 1-40 -induced mitochondrial and cytosolic ROS production in VSMC

Supp8.jpeg (56 kB)
Transformed rat cerebral VSMC behave similarly to human cerebral VSMC with respect to Aβ 1-40 -induced ROS production and mitigation of Aβ 1-40 -induced oxidative stress by pharmacological knockdown of HSPG with heparinase

Supp9.jpeg (44 kB)
Human VSMC cells also show Aβ 1-40 induces HSPG-mediated Ca 2+ influx

Share

COinS