Journal
Nature Communications
Publication Date
2016
Volume
7
Inclusive Pages
11853
Document Type
Open Access Publication
DOI
10.1038/ncomms11853
Rights and Permissions
G.J. Randolph, et al. 24 June 2016. Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. Nature communications. Art. No. 11853. DOI: 10.1038/ncomms11853. http://www.nature.com/ncomms/2016/160624/ncomms11853/full/ncomms11853.html
Recommended Citation
Randolph, Gwendalyn J. and et al, "Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability." Nature Communications. 7, 11853. (2016).
https://digitalcommons.wustl.edu/open_access_pubs/5086
ncomms11853-s3.pdf (3853 kB)
Supplementary Figures 1-21, Supplementary Tables 1-6 and Supplementary References
ncomms11853-s1.avi (61442 kB)
Endothelial lineage-derived Yfp+ cells undergo EndMT and give rise to Fap+ fibroblast-like cells within intimal plaques. Immunofluorescence confocal microscopy with z-stack acquisition of a thoracic aortic section from a tamoxifen-induced end. SclCreERT;R26RstopYfp;ApoE-/- mice fed with 30 weeks of HFD revealed intimal plaque Yfp+ cells co-expressing the fibroblast marker Fap. Movie corresponds to the same section as displayed in Fig. 2c.
ncomms11853-s2.avi (61442 kB)
Supplementary Figures 1-21, Supplementary Tables 1-6 and Supplementary References
ncomms11853-s1.avi (61442 kB)
Endothelial lineage-derived Yfp+ cells undergo EndMT and give rise to Fap+ fibroblast-like cells within intimal plaques. Immunofluorescence confocal microscopy with z-stack acquisition of a thoracic aortic section from a tamoxifen-induced end. SclCreERT;R26RstopYfp;ApoE-/- mice fed with 30 weeks of HFD revealed intimal plaque Yfp+ cells co-expressing the fibroblast marker Fap. Movie corresponds to the same section as displayed in Fig. 2c.
ncomms11853-s2.avi (61442 kB)
