Journal
Cell Reports
Publication Date
2017
Volume
18
Issue
12
Inclusive Pages
2893-2906
Document Type
Open Access Publication
DOI
10.1016/j.celrep.2017.02.074
Rights and Permissions
Nargund AM, Pham CG, Dong Y, et al (2017) The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Reports, 18(12): 2893-2906. http://doi.org/10.1016/j.celrep.2017.02.074 Copyright 2017 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Recommended Citation
Hsieh, James J. and et al, "The SWI/SNF protein PBRM1 restrains VHL-loss-driven clear cell renal cell carcinoma." Cell Reports. 18, 12. 2893-2906. (2017).
https://digitalcommons.wustl.edu/open_access_pubs/5756
mmc1 (3).pdf.crdownload (26168 kB)
Document S1. Supplemental Experimental Procedures and Figures S1–S7.
mmc2.xlsx (26 kB)
Table S1. Gross and Histopathological Analyses of Mice, Related to Figures 3, S4, and S5.
mmc3.xlsx (819 kB)
Table S2. Differential Gene Expression and KEGG Pathway Analysis of 12-Week-Old Mice across the Indicated Genotypes, Including WT, VhlF/FKsp-Cre, Pbrm1F/FKsp-Cre, and VhlF/FPbrm1F/FKsp-Cre as Determined by Microarray.
mmc4.xlsx (398 kB)
Table S3. Genes that Are Differentially Expressed among Five VhlF/FPbrm1F/FKsp-Cre Tumor Samples and Four Age-Matched WT Normal Kidney Samples Determined by RNA-Seq, Related to Figure 6.
mmc5.xlsx (20 kB)
Table S4. KEGG Pathways Overrepresented in the Genes that Are Differentially Expressed among Five VhlF/FPbrm1F/FKsp-Cre Tumor Samples and Four Age-Matched WT Normal Kidney Samples as Tested by ClueGO, Related to Figure 6.
mmc6.xlsx (15 kB)
Table S5. KEGG Pathways Overrepresented in the Set of Differentially Expressed Genes that Is Common between VhlF/FPbrm1F/FKsp-Cre Mouse ccRCC Tumors versus Normal and Hif1α-M3 TRACK Mouse ccRCC Tumors versus Normal as Determined by ClueGO, Related to Figure 7.
mmc7.xlsx (21 kB)
Table S6. KEGG Pathways Overrepresented in the Shared Differentially Expressed Genes between VhlF/FPbrm1F/FKsp-Cre Mouse ccRCC Tumors versus Normal, Hif1α-M3 TRACK Mouse ccRCC Tumors versus Normal, and TCGA VHLmtPBRM1mt Human ccRCC Tumors versus Normal as Determined by ClueGO, Related to Figure 7.
mmc8.xlsx (10 kB)
Table S7. Primers for qRT-PCR, Related to Figures 5, 6, S5, and S6.
mmc9.pdf (37195 kB)
Document S2. Article plus Supplemental Information.
Document S1. Supplemental Experimental Procedures and Figures S1–S7.
mmc2.xlsx (26 kB)
Table S1. Gross and Histopathological Analyses of Mice, Related to Figures 3, S4, and S5.
mmc3.xlsx (819 kB)
Table S2. Differential Gene Expression and KEGG Pathway Analysis of 12-Week-Old Mice across the Indicated Genotypes, Including WT, VhlF/FKsp-Cre, Pbrm1F/FKsp-Cre, and VhlF/FPbrm1F/FKsp-Cre as Determined by Microarray.
mmc4.xlsx (398 kB)
Table S3. Genes that Are Differentially Expressed among Five VhlF/FPbrm1F/FKsp-Cre Tumor Samples and Four Age-Matched WT Normal Kidney Samples Determined by RNA-Seq, Related to Figure 6.
mmc5.xlsx (20 kB)
Table S4. KEGG Pathways Overrepresented in the Genes that Are Differentially Expressed among Five VhlF/FPbrm1F/FKsp-Cre Tumor Samples and Four Age-Matched WT Normal Kidney Samples as Tested by ClueGO, Related to Figure 6.
mmc6.xlsx (15 kB)
Table S5. KEGG Pathways Overrepresented in the Set of Differentially Expressed Genes that Is Common between VhlF/FPbrm1F/FKsp-Cre Mouse ccRCC Tumors versus Normal and Hif1α-M3 TRACK Mouse ccRCC Tumors versus Normal as Determined by ClueGO, Related to Figure 7.
mmc7.xlsx (21 kB)
Table S6. KEGG Pathways Overrepresented in the Shared Differentially Expressed Genes between VhlF/FPbrm1F/FKsp-Cre Mouse ccRCC Tumors versus Normal, Hif1α-M3 TRACK Mouse ccRCC Tumors versus Normal, and TCGA VHLmtPBRM1mt Human ccRCC Tumors versus Normal as Determined by ClueGO, Related to Figure 7.
mmc8.xlsx (10 kB)
Table S7. Primers for qRT-PCR, Related to Figures 5, 6, S5, and S6.
mmc9.pdf (37195 kB)
Document S2. Article plus Supplemental Information.
