Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Authors

Shan Jiang, Washington University School of Medicine in St. Louis
Natalie Wen, Washington University School of Medicine in St. Louis
Zeran Li, Washington University School of Medicine in St. Louis
Umber Dube, Washington University School of Medicine in St. Louis
Jorge Del Aguila, Washington University School of Medicine in St. Louis
John Budde, Washington University School of Medicine in St. Louis
Rita Martinez, Washington University School of Medicine in St. Louis
Simon Hsu, Washington University School of Medicine in St. Louis
Maria V. Fernandez, Washington University School of Medicine in St. Louis
Nigel J. Cairns, Washington University School of Medicine in St. Louis
Oscar Harari, Washington University School of Medicine in St. Louis
Carlos Cruchaga, Washington University School of Medicine in St. Louis
Celeste M. Karch, Washington University School of Medicine in St. Louis
International FTD-Genomics Consortium

Journal

Translational Psychiatry

Publication Date

2018

Volume

8

Issue

265

Inclusive Pages

1-16

Document Type

Open Access Publication

DOI

10.1038/s41398-018-0319-z

Rights and Permissions

Shan Jiang, Natalie Wen, Zeran Li, Umber Dube, Jorge Del Aguila, John Budde, Rita Martinez, Simon Hsu, Maria V. Fernandez, Nigel J. Cairns, Dominantly Inherited Alzheimer Network (DIAN), International FTD-Genomics Consortium (IFGC), Oscar Harari, Carlos Cruchaga & Celeste M. Karch. 2018. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP. Translational Psychiatry 8, e265. doi: 10.1038/s41398-018-0319-z. https://www.nature.com/articles/s41398-018-0319-z. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Jiang, Shan; Wen, Natalie; Li, Zeran; Dube, Umber; Aguila, Jorge Del; Budde, John; Martinez, Rita; Hsu, Simon; Fernandez, Maria V.; Cairns, Nigel J.; Harari, Oscar; Cruchaga, Carlos; Karch, Celeste M.; and International FTD-Genomics Consortium, "Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP." Translational Psychiatry. 8, 265. 1-16. (2018).
https://digitalcommons.wustl.edu/open_access_pubs/7353