Journal
Kidney International
Publication Date
2018
Volume
93
Issue
3
Inclusive Pages
741-752
Document Type
Open Access Publication
DOI
10.1016/j.kint.2017.08.033
Rights and Permissions
Xie Y, Bowe B, Li T, Xian H, Yan Y, Al-Aly Z (2018) Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus. Kidney International, 93(3):741-752. https://doi.org/10.1016/j.kint.2017.08.033 Published by Elsevier, Inc., on behalf of the International Society ofNephrology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Recommended Citation
Xie, Yan; Bowe, Benjamin; Li, Tingting; Xian, Hong; Yan, Yan; and Al-Aly, Ziyad, "Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus." Kidney International. 93, 3. 741-752. (2018).
https://digitalcommons.wustl.edu/open_access_pubs/7530
1-s2.0-S0085253817306762-mmc1.pptx (88 kB)
Figure S1. Joint risk of incident diabetes mellitus by body mass index and estimated glomerular filtration rate (eGFR) category.
1-s2.0-S0085253817306762-mmc2.pptx (53 kB)
Figure S2. Joint risk of incident diabetes mellitus by body mass index and blood urea nitrogen (BUN) (≤ 25 and >25 mg/dl) category.
1-s2.0-S0085253817306762-mmc3.pptx (93 kB)
Figure S3. Joint risk of incident diabetes mellitus by body mass index and blood urea nitrogen (BUN) (in quintiles) category.
1-s2.0-S0085253817306762-mmc4.pptx (68 kB)
Figure S4. Spline analysis of the relationship between time-updated log10 estimated glomerular filtration rate (eGFR) and the risk of incident diabetes mellitus; eGFR = 120 ml/min per 1.73 m2 (log10 eGFR = 2.08) was the reference.
1-s2.0-S0085253817306762-mmc5.pptx (69 kB)
Figure S5. Spline analysis of the relationship between time-updated log10 blood urea nitrogen (BUN) level and the risk of incident diabetes mellitus. BUN = 5 mg/dl (log10 BUN = 0.70) was the reference.
1-s2.0-S0085253817306762-mmc6.pptx (70 kB)
Figure S6. Spline analysis of risk of incident diabetes mellitus including both time-updated log10 estimated glomerular filtration rate (eGFR) and log10 blood urea nitrogen (BUN). eGFR = 120 ml/min per 1.73 m2 and BUN = 5 mg/dl were the reference points.
1-s2.0-S0085253817306762-mmc7.docx (23 kB)
Table S1. Baseline characteristics according to estimated glomerular filtration rate category at time of cohort entry (T0).
1-s2.0-S0085253817306762-mmc8.docx (15 kB)
Table S2. Joint model of the risk of incident diabetes mellitus by time-updated BUN categorized in quintiles and estimated glomerular filtration rate categories.
1-s2.0-S0085253817306762-mmc9.docx (14 kB)
Table S3. Joint risk model of the risk of incident diabetes mellitus by time-updated body mass index and estimated glomerular filtration rate category.
1-s2.0-S0085253817306762-mmc10.docx (14 kB)
Table S4. Joint risk model of the risk of incident diabetes mellitus by time-updated body mass index and blood urea nitrogen (>25 and ≤25 mg/dl) category.
1-s2.0-S0085253817306762-mmc11.docx (15 kB)
Table S5. Joint risk model of the risk of incident diabetes mellitus by time-updated BMI and BUN (in quintiles) category.
1-s2.0-S0085253817306762-mmc12.docx (14 kB)
Table S6. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category additionally controlled for gastrointestinal bleeding.
1-s2.0-S0085253817306762-mmc13.docx (14 kB)
Table S7. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category additionally controlled for steroids.
1-s2.0-S0085253817306762-mmc14.docx (14 kB)
Table S8. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category in which estimated glomerular filtration rate was computed using the MDRD (Modification of Diet in Renal Disease) study equation.
1-s2.0-S0085253817306762-mmc15.docx (14 kB)
Table S9. Joint model of the risk of incident diabetes mellitus by a time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants who experienced albuminuria during follow-up were excluded (N = 1,062,505).
1-s2.0-S0085253817306762-mmc16.docx (14 kB)
Table S10. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants who experienced albuminuria within 5 years before cohort entry (T0) were excluded (N = 1,168,611).
1-s2.0-S0085253817306762-mmc17.docx (14 kB)
Table S11. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants with diabetic retinopathy during follow-up were excluded (N = 1,330,981).
1-s2.0-S0085253817306762-mmc18.docx (14 kB)
Table S12. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants with secondary diabetes mellitus during follow-up were excluded (N = 1,336,422).
1-s2.0-S0085253817306762-mmc19.docx (14 kB)
Table S13. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category additionally controlled for number of estimated glomerular filtration rate and blood urea nitrogen measurements.
Figure S1. Joint risk of incident diabetes mellitus by body mass index and estimated glomerular filtration rate (eGFR) category.
1-s2.0-S0085253817306762-mmc2.pptx (53 kB)
Figure S2. Joint risk of incident diabetes mellitus by body mass index and blood urea nitrogen (BUN) (≤ 25 and >25 mg/dl) category.
1-s2.0-S0085253817306762-mmc3.pptx (93 kB)
Figure S3. Joint risk of incident diabetes mellitus by body mass index and blood urea nitrogen (BUN) (in quintiles) category.
1-s2.0-S0085253817306762-mmc4.pptx (68 kB)
Figure S4. Spline analysis of the relationship between time-updated log10 estimated glomerular filtration rate (eGFR) and the risk of incident diabetes mellitus; eGFR = 120 ml/min per 1.73 m2 (log10 eGFR = 2.08) was the reference.
1-s2.0-S0085253817306762-mmc5.pptx (69 kB)
Figure S5. Spline analysis of the relationship between time-updated log10 blood urea nitrogen (BUN) level and the risk of incident diabetes mellitus. BUN = 5 mg/dl (log10 BUN = 0.70) was the reference.
1-s2.0-S0085253817306762-mmc6.pptx (70 kB)
Figure S6. Spline analysis of risk of incident diabetes mellitus including both time-updated log10 estimated glomerular filtration rate (eGFR) and log10 blood urea nitrogen (BUN). eGFR = 120 ml/min per 1.73 m2 and BUN = 5 mg/dl were the reference points.
1-s2.0-S0085253817306762-mmc7.docx (23 kB)
Table S1. Baseline characteristics according to estimated glomerular filtration rate category at time of cohort entry (T0).
1-s2.0-S0085253817306762-mmc8.docx (15 kB)
Table S2. Joint model of the risk of incident diabetes mellitus by time-updated BUN categorized in quintiles and estimated glomerular filtration rate categories.
1-s2.0-S0085253817306762-mmc9.docx (14 kB)
Table S3. Joint risk model of the risk of incident diabetes mellitus by time-updated body mass index and estimated glomerular filtration rate category.
1-s2.0-S0085253817306762-mmc10.docx (14 kB)
Table S4. Joint risk model of the risk of incident diabetes mellitus by time-updated body mass index and blood urea nitrogen (>25 and ≤25 mg/dl) category.
1-s2.0-S0085253817306762-mmc11.docx (15 kB)
Table S5. Joint risk model of the risk of incident diabetes mellitus by time-updated BMI and BUN (in quintiles) category.
1-s2.0-S0085253817306762-mmc12.docx (14 kB)
Table S6. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category additionally controlled for gastrointestinal bleeding.
1-s2.0-S0085253817306762-mmc13.docx (14 kB)
Table S7. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category additionally controlled for steroids.
1-s2.0-S0085253817306762-mmc14.docx (14 kB)
Table S8. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category in which estimated glomerular filtration rate was computed using the MDRD (Modification of Diet in Renal Disease) study equation.
1-s2.0-S0085253817306762-mmc15.docx (14 kB)
Table S9. Joint model of the risk of incident diabetes mellitus by a time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants who experienced albuminuria during follow-up were excluded (N = 1,062,505).
1-s2.0-S0085253817306762-mmc16.docx (14 kB)
Table S10. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants who experienced albuminuria within 5 years before cohort entry (T0) were excluded (N = 1,168,611).
1-s2.0-S0085253817306762-mmc17.docx (14 kB)
Table S11. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants with diabetic retinopathy during follow-up were excluded (N = 1,330,981).
1-s2.0-S0085253817306762-mmc18.docx (14 kB)
Table S12. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category from which participants with secondary diabetes mellitus during follow-up were excluded (N = 1,336,422).
1-s2.0-S0085253817306762-mmc19.docx (14 kB)
Table S13. Joint model of the risk of incident diabetes mellitus by time-updated estimated glomerular filtration rate and blood urea nitrogen category additionally controlled for number of estimated glomerular filtration rate and blood urea nitrogen measurements.
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