Journal
Elife
Publication Date
8-20-2019
Volume
8
First Page
e46677
Document Type
Open Access Publication
DOI
10.7554/eLife.46677
Rights and Permissions
Yu L, O'Brien VP, Livny J, Dorsey D, Bandyopadhyay N, Colonna M, Caparon MG, Roberson ED, Hultgren SJ, Hannan TJ. Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence. Elife. 2019 Aug 20;8. doi: 10.7554/eLife.46677. © 2019, Yu et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Yu, Lu; O'Brien, Valerie P.; Livny, Jonathan; Dorsey, Denise; Bandyopadhyay, Nirmalya; Colonna, Marco; Caparon, Michael G.; Roberson, Elisha D.O.; Hultgren, Scott J.; and Hannan, Thomas, "Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence." Elife. 8, e46677 (2019).
https://digitalcommons.wustl.edu/open_access_pubs/8712
elife-46677-fig1-data1-v2.xlsx (9 kB)
Infection history alters acute bladder inflammation kinetics during recurrent UTI
elife-46677-fig2-data1-v2.xlsx (12 kB)
Infection history alters the course of bladder pathophysiology during recurrent UTI
elife-46677-fig3-data1-v2.xlsx (8 kB)
Isogenic mice with different infection histories showed distinct bladder transcriptomic profile kinetics
elife-46677-fig4-data1-v2.xlsx (8 kB)
TNFα receptor pathway activation dynamics correlate with host susceptibility to recurrent cystitis
elife-46677-fig5-data1-v2.xlsx (12 kB)
TNFα depletion increases intracellular bladder bacterial burdens in Resolved mice during acute rUTI
elife-46677-fig6-data1-v2.xlsx (10 kB)
TNFα signaling restricts bladder intracellular colonization by UPEC in Resolved mice by promoting the exfoliation of infected bladder epithelial cells
elife-46677-fig7-data1-v2.xlsx (11 kB)
TNFα-depletion decreases the severity of acute rUTI in Sensitized mice
Supplementary file 1.xlsx (114 kB)
Supplementary file 2.xlsx (19 kB)
Supplementary file 3.xlsx (17 kB)
Transparent reporting form.pdf (304 kB)
