Mass spectrometry– based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells

Authors

Ian M. McDonald, University of North Carolina at Chapel Hill
Gavin D. Grant, University of North Carolina at Chapel Hill
Michael P. East, University of North Carolina at Chapel Hill
Thomas S.K. Gilbert, University of North Carolina at Chapel Hill
Emily M. Wilkerson, University of North Carolina at Chapel Hill
Dennis Goldfarb, Washington University School of Medicine in St. Louis
Joshua Beri, University of North Carolina at Chapel Hill
Laura E. Herring, University of North Carolina at Chapel Hill
Cyrus Vaziri, University of North Carolina at Chapel Hill
Jeanette Gowen Cook, University of North Carolina at Chapel Hill
Michael J. Emanuele, University of North Carolina at Chapel Hill
Lee M. Graves, University of North Carolina at Chapel Hill

Journal

Journal of Biological Chemisty

Publication Date

2020

Volume

295

Issue

8

First Page

2359

Last Page

2374

Document Type

Open Access Publication

DOI

10.1074/jbc.RA119.011083

Rights and Permissions

This research was originally published in Journal of Biological Chemistry. McDonald, I. M., Grant, G. D., East, M. P., Gilbert, T. S. K., Wilkerson, E. M., Goldfarb, D., . . . Graves, L. M. (2020). Mass spectrometry– based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells. Journal of Biological Chemistry, 295(8), 2359-2374. doi:10.1074/jbc.RA119.011083 © the American Society for Biochemistry and Molecular Biology.

Recommended Citation

McDonald, Ian M.; Grant, Gavin D.; East, Michael P.; Gilbert, Thomas S.K.; Wilkerson, Emily M.; Goldfarb, Dennis; Beri, Joshua; Herring, Laura E.; Vaziri, Cyrus; Cook, Jeanette Gowen; Emanuele, Michael J.; and Graves, Lee M., "Mass spectrometry– based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells." Journal of Biological Chemisty. 295, 8. 2359 - 2374. (2020).
https://digitalcommons.wustl.edu/open_access_pubs/8928