Journal
Elife
Publication Date
7-29-2020
Volume
9
First Page
e56882
Document Type
Open Access Publication
DOI
10.7554/eLife.56882
Rights and Permissions
Piersma SJ, Poursine-Laurent J, Yang L, Barber GN, Parikh BA, Yokoyama WM. Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. Elife. 2020;9:e56882. Published 2020 Jul 29. doi:10.7554/eLife.56882. © 2020, Piersma et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Piersma, Sytse J.; Poursine-Laurent, Jennifer; Yang, Liping; Barber, Glen N.; Parikh, Bijal A.; and Yokoyama, Wayne M., "Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING." Elife. 9, e56882 (2020).
https://digitalcommons.wustl.edu/open_access_pubs/9350
elife-56882-fig1-data1-v2.xlsx (15 kB)
MyD88 and STING control morbidity and mortality during MCMV infection.
elife-56882-fig2-data1-v2.xlsx (11 kB)
STING contributes to control of MCMV in the hematological and stromal compartment, whereas MyD88 in the hematological compartment potently controls infection
elife-56882-fig3-data1-v2.xlsx (9 kB)
MCMV-infected cells specifically produce IFNβ upon infection
elife-56882-fig4-data1-v2.xlsx (9 kB)
pDCs produce IFNβ in a MyD88-dependent but STING-independent manner in IFNβ-YFP reporter mice
elife-56882-fig5-data1-v2.xlsx (10 kB)
MCMV-induced fibroblast IFNβ is triggered by cGAS-STING-dependent but MyD88-Trif-MAVS-independent mechanisms
elife-56882-fig6-data1-v2.xlsx (9 kB)
MyD88 and STING are required for NK cell cytolytic capacity during MCMV infection
Transparent reporting form.docx (66 kB)
