Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance

Authors

Cameron A. Brown, Baylor College of Medicine
Liya Hu, Baylor College of Medicine
Zhizeng Sun, Baylor College of Medicine
Meha P. Patel, Baylor College of Medicine
Sukrit Singh, Washington University School of Medicine in St. Louis
Justin R. Porter, Washington University School of Medicine in St. Louis
Banumathi Sankaran, Lawrence Berkeley National Laboratory
B. V. Venkataram Prasad, Baylor College of Medicine
Gregory R. Bowman, Washington University School of Medicine in St. Louis
Timothy Palzkill, Baylor College of Medicine

Journal

Journal of Biological Chemistry

Publication Date

2020

Volume

295

Issue

21

First Page

7376

Last Page

7390

Document Type

Open Access Publication

DOI

10.1074/jbc.RA119.012489

Rights and Permissions

This research was originally published in Journal of Biological Chemistry. Brown, C. A., Hu, L., Sun, Z., Patel, M. P., Singh, S., Porter, J. R., . . . Palzkill, T. (2020). Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance. Journal of Biological Chemistry, 295(21), 7376-7390. doi:10.1074/jbc.RA119.012489 © the American Society for Biochemistry and Molecular Biology.

Recommended Citation

Brown, Cameron A.; Hu, Liya; Sun, Zhizeng; Patel, Meha P.; Singh, Sukrit; Porter, Justin R.; Sankaran, Banumathi; Venkataram Prasad, B. V.; Bowman, Gregory R.; and Palzkill, Timothy, "Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance." Journal of Biological Chemistry. 295, 21. 7376 - 7390. (2020).
https://digitalcommons.wustl.edu/open_access_pubs/9399