Journal
Elife
Publication Date
2020
Volume
9
First Page
e55331
Document Type
Open Access Publication
DOI
10.7554/eLife.55331
Rights and Permissions
eLife 2020;9:e55331 DOI: 10.7554/eLife.55331. © 2020, Sugasawa et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Recommended Citation
Sugasawa, Yusuke; Cheng, Wayland W.L.; Bracamontes, John R.; Chen, Zi-Wei; Wang, Lei; Germann, Allison L.; Pierce, Spencer R.; Senneff, Thomas C.; Krishnan, Kathiresan; Reichert, David E.; Covey, Douglas F.; Akk, Gustav; and Evers, Alex S., "Site-specific effects of neurosteroids on GABA(A) receptor activation and desensitization." Elife. 9, e55331 (2020).
https://digitalcommons.wustl.edu/open_access_pubs/9682
Figures and figure supplements (2).pdf (4853 kB)
elife-55331-transrepform-v2.pdf (161 kB)
Transparent Reporting Form
Figure 7—source data 1.docx (13 kB)
Properties of [3H]muscimol binding isotherms in α1β3 WT and mutant GABAARs.
Figure 7—source data 2.docx (16 kB)
Properties of neurosteroid effect on [3H]muscimol binding isotherms in α1β3 GABAAR WT and α1(N408A/Y411F)β3 mutant.
Figure 11—source data 1.docx (13 kB)
Vina docking scores for allopregnanolone and epi-allopregnanolone at each site in α1β3 model and α1β3γ2 GABAAR structure.
elife-55331-transrepform-v2.pdf (161 kB)
Transparent Reporting Form
Figure 7—source data 1.docx (13 kB)
Properties of [3H]muscimol binding isotherms in α1β3 WT and mutant GABAARs.
Figure 7—source data 2.docx (16 kB)
Properties of neurosteroid effect on [3H]muscimol binding isotherms in α1β3 GABAAR WT and α1(N408A/Y411F)β3 mutant.
Figure 11—source data 1.docx (13 kB)
Vina docking scores for allopregnanolone and epi-allopregnanolone at each site in α1β3 model and α1β3γ2 GABAAR structure.
