Glanzmann thrombasthenia: genetic basis and clinical correlates

Juliana Perez Botero, Medical College of Wisconsin
Kristy Lee, University of North Carolina at Chapel Hill
Brian R. Branchford, University of Colorado, Denver
Paul F. Bray, University of Utah
Kathleen Freson, University of Leuven
Michele P. Lambert, Pereleman School of Medicine
Minjie Luo, Pereleman School of Medicine
Shruthi Mohan, University of North Carolina at Chapel Hill
Justyne E. Ross, University of North Carolina at Chapel Hill
Wolfgang Bergmeier, University of North Carolina at Chapel Hill
Jorge Di Paola, Washington University School of Medicine in St. Louis

Abstract

Glanzmann thrombasthenia (GT) is an autosomal recessive disorder of platelet aggregation caused by quantitative or qualitative defects in integrins αIIb and β3. These integrins are encoded by the