Issue Date
2011
Abstract
Three separate theories of inhibiting cisplatin-induced apoptosis were investigated utilizing different cellular mechanisms. Specifically, the copper transport cycle, TRPV1, and the JNK pathway were inhibited and immunohistochemistry was performed to determine levels of apoptosis. All three resulted in statistically significant effects; increasing CuSO4 levels resulted in increased apoptosis, and inhibiting TRPV1
Language
English
Publisher
Program in Audiology and Communication Sciences, Washington University School of Medicine
Document Type
Thesis
Advisor
Warchol, Mark
Recommended Citation
Yarnell, Lindsey M., "Cellular signals of cisplatin ototoxicity" (2011). Independent Studies and Capstones. Paper 616. Program in Audiology and Communication Sciences, Washington University School of Medicine.
https://digitalcommons.wustl.edu/pacs_capstones/616
