Issue Date
2012
Abstract
Hair cell death and regeneration on the zebrafish posterior lateral line was investigated after cisplatin administration. Hair cell regeneration was first observed by 24 hours of recovery and was further analyzed after specific recovery intervals. Disruption of the notch signaling pathways by the y-secretase inhibitor DAPT resulted in an increase in hair cells at three days of recovery.
Language
English
Publisher
Program in Audiology and Communication Sciences, Washington University School of Medicine
Subject (MeSH)
Cisplatin; Zebrafish
Subject (LC)
Hair cells--Regeneration
Document Type
Thesis
Advisor
Warchol, Mark
Recommended Citation
Genualdi, Alisa A., "Cisplatin ototoxicity and hair cell regeneration in the zebrafish lateral line" (2012). Independent Studies and Capstones. Paper 646. Program in Audiology and Communication Sciences, Washington University School of Medicine.
https://digitalcommons.wustl.edu/pacs_capstones/646
