Issue Date

2013

Abstract

Supporting cell proliferation patterns were assessed in the three most posterior neuromasts of zebrafish larvae following treatment with 1000 μM cisplatin. Proliferation was upregulated 48 to 72 hours post-exposure, but survival of internal supporting cell progeny was low three days after treatment. This finding may account for why hair cell regeneration is delayed or absent after cisplatin administration.

Language

English

Publisher

Program in Audiology and Communication Sciences, Washington University School of Medicine

Subject (MeSH)

Cisplatin/toxicity; Hair Cells, Auditory

Subject (LC)

Regeneration (Physiology)

Document Type

Thesis

Advisor

Warchol, Mark

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