The stria vascularis generates the endocochlear potential (EP), which relies on the maintenance of ionic boundaries. Strial and spiral ligament capillary permeability to FITC-conjugated dextrans and other tracers was assessed in mice of different strains, with and without prior systemic application of mannitol. Mannitol appeared to increase strial capillary permeability to 4 kDa FITC-dextran and effects of mannitol were clearest for post-injection times of less than 2 hours. Present results agree with previous work in suggesting that cochlear capillaries are very ‘leaky’ under normal conditions.
Program in Audiology and Communication Sciences, Washington University School of Medicine
Stria Vascularis; Capillary Permeability; Mice
Ohlemiller, Kevin K.
Fahrenthold, Kaela Christine, "Strial capillary permeability studied with fluorescent tracers in inbred mice" (2015). Independent Studies and Capstones. Paper 714. Program in Audiology and Communication Sciences, Washington University School of Medicine.