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Submissions from 2017

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Glucocorticoids for treating paediatric pulmonary hypertension: A novel use for a common medication, Manish Aggarwal and Ronald M. Grady

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Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets, Norma Corona de la Pena, Manuel Gutierrez-Aguilar, Ileana Hernandez-Resendiz, Alvaro Marin-Hernandez, and Sara Rodriguez-Enriquez

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Group and individual variability in mouse pup isolation calls recorded on the same day show stability, Terra D. Barnes, Michael A. Rieger, Joseph D. Dougherty, and Timothy E. Holy

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Hand classification of fMRI ICA noise components, Ludovica Griffanti, Gwenaelle Douaud, Janine Bijsterbosch, Stefania Evangelisti, Fidel Alfaro-Almagro, Matthew F. Glasser, Eugene P. Duff, Sean Fitzgibbon, Robert Westphal, Davide Carone, Christian F. Beckmann, and Stephen M. Smith

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Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies, Christopher B. Cole, David A. Russler-Germain, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Nichole M. Helton, Mindy Guo, Jeffery M. Klco, Shelly O'Laughlin, Catrina Fronick, Robert Fulton, Gue Su Chang, Allegra A. Petti, Christopher A. Miller, and Timothy J. Ley

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Harmonizing the paradigm with the data in stable coronary artery disease: A review and viewpoint, Joshua D. Mitchell and David L. Brown

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Heat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function, Wen Li, Ashley N. Reeb, Binyan Lin, Praveen Subramanian, Erin E. Fey, Catherine R. Knoverek, Rachel L. French, Eileen H. Bigio, and Yuna M. Ayala

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Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice, Yu Shi and Fanxin Long

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Hematologic safety of radium-223 dichloride: Baseline prognostic factors associated with myelosuppression in the ALSYMPCA trial, Nicholas J. Vogelzang, Robert E. Coleman, Jeff M. Michalski, Sten Nilsson, Joe M. O'Sullivan, Christopher Parker, Anders Widmark, Marcus Thuresson, Lei Xu, Joseph Germino, and Oliver Sartor

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Hemobilia due to cystic artery pseudoaneurysm: A rare late complication of laparoscopic cholecystectomy, Ricardo Badillo, Michael D. Darcy, and Vladimir M. Kushnir

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Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment, Benjamin Yaw Owusu, Robert Galemmo, James Janetka, and Lidija Klampfer

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Herpes simplex keratitis: Challenges in diagnosis and clinical management, Tayaba N. Azher, Xiao-Tang Yin, Deena Tajfirouz, Andrew JW Huang, and Patrick M. Stuart

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Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae, Kathryn M. Keefer, Kevin C. Stein, and Heather L. true

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Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling, Susan K. Grimston, Francesca Fontana, Marcus Watkins, and Roberto Civitelli

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HID-1 controls formation of large dense core vesicles by influencing cargo sorting and trans-Golgi network acidification, Blake H. Hummer, Noah F. de Leeuw, Christian Burns, Lan Chen, Matthew S. Joens, Bethany Hosford, James A. J. Fitzpatrick, and Cedric S. Asensio

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High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain, Tanja Dragojevic, Hari M. Varma, Joseph L. Hollmann, Claudia P. Valdes, Joseph P. Culver, Carles Justicia, and Turgut Durduran

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Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions, Alaullah Sheikh, Rasheduzzaman Rashu, Yasmin Ara Begum, F. Matthew Kuhlman, Matthew A. Ciorba, Scott J. Hultgren, Firdausi Qadri, and James M. Fleckenstein

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Hip dysplasia in wrestlers: Three lessons learned, J. W. Thomas Byrd, John C. Clohisy, Young-Jo Kim, F. Winston Gwathmey, Kay S. Jones, and Michael B. Millis

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Hippocampal slice preparation in rats acutely suppresses immunoreactivity of microtubule-associated protein (Map2) and glycogen levels without affecting numbers of glia or levels of the glutamate transporter VGlut1, Liana R. Stein, Charles F. Zorumski, and Yukitoshi Izumi

Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis, Peng Shao, Qi Liu, Peterson Kariuki Maina, Jiayue Cui, Thomas B. Bair, Tiandao Li, Shaikamjad Umesalma, Weizhou Zhang, and Hank Heng Qi

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HLA-Bw4-I-80 isoform differentially influences clinical outcome as compared to HLA-Bw4-T-80 and HLA-A-Bw4 isoforms in rituximab or dinutuximab-based cancer immunotherapy, Brad Kahl and et al

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Homeostatic plasticity shapes the visual system’s first synapse, Robert E. Johnson, Nai-Wen Tien, Ning Shen, James T. Pearson, Florentina Soto, and Daniel Kerschensteiner

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Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection, Wei Xu, Ana L. Flores-Mireles, Zachary T. Cusumano, Enzo Takagi, Scott J. Hultgren, and Michael G. Caparon

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Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome, Shondra M. Pruett-Miller and et al

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How should novelty be valued in science?, Barak A. Cohen

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How to tell a happy from an unhappy schizotype: Personality factors and mental health outcomes in individuals with psychotic experiences, Leticia O. Alminhana, Miguel Farias, Gordon Claridge, Claude R. Cloninger, and Alexander Moreira-Almeida

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HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice, Alison K. Esser, Daniel A. Rauch, Jingyu Xiang, John C. Harding, Michael H. Ross, Xinming Su, Kevin Wu, Yalin Xu, Kiran Vij, Lee Ratner, Katherine N. Weilbaecher, and et al

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Human embryos cultured in vitro to 14 days, Samantha A. Morris

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Human milk oligosaccharides inhibit growth of group B Streptococcus, Ann E. Lin, Chloe A. Autran, Alexandra Szyszka, Tamara Escajadillo, Mia Huang, Kamil Godula, Anthony R. Pudden, Geert-Jan Boons, Amanda L. Lewis, Kelly S. Doran, Victor Nizet, and Lars Bode

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Human perception of electrical stimulation on the surface of somatosensory cortex, Shivayogi V. Hiremath, Elizabeth C. Tyler-Kabara, Jesse J. Wheeler, Daniel W. Moran, Robert A. Gaunt, Jennifer L. Collinger, Stephen T. Foldes, Douglas J. Weber, Weidong Chen, Michael L. Boninger, and Wei Wang

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Human primary macrophages derived in vitro from circulating monocytes comprise adherent and non-adherent subsets with differential expression of Siglec-1 and CD4 and permissiveness to HIV-1 infection, Ousman Jobe, Jiae Kim, Eric Tycksen, Sayali Onkar, Nelson L. Michael, Carl R. Alving, and Mangala Rao

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Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork, Shankar Parajuli, Daniel C. Teasley, Bhavna Murali, Jessica Jackson, Alessandro Vindigni, and Sheila A. Stewart

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Human summating potential using continuous loop averaging deconvolution: Response amplitudes vary with tone burst repetition rate and duration, Alana E. Kennedy, Wafaa A. Kaf, John A. Ferraro, Rafael E. Delgado, and Jeffery T. Lichtenhan

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Hydraulic forces contribute to left ventricular diastolic filling, Elira Maksuti, Marcus Carlsson, Hakan Arheden, Sandor J. Kovacs, Michael Broome, and Martin Ugander

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Hydrogel spacer distribution within the perirectal space in patients undergoing radiotherapy for prostate cancer: Impact of spacer symmetry on rectal dose reduction and the clinical consequences of hydrogel infiltration into the rectal wall, Benjamin W. Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, and Jeff Michalski

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Hyperspectral imaging for simultaneous measurements of two FRET biosensors in pancreatic β-cells, Amicia D. Elliott, Noah Bedard, Alessandro Ustione, Michelle A. Baird, Michael W. Davidson, Tomasz Tkaczyk, and David W. Piston

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ICD-9-CM coding for multidrug resistant infection correlates poorly with microbiologically confirmed multidrug resistant infection, Jason P. Burnham, Jennie H. Kwon, Hilary M. Babcock, Margaret A. Olsen, and Marin H. Kollef

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Identification of a Sjogren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons, Andrew J. W. Huang and et al.

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Identification of genes that maintain behavioral and structural plasticity during sleep loss, Laurent Seugnet, Stephane Dissel, Matthew Thimgan, Lijuan Cao, and Paul J. Shaw

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IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α, Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W. Linhoff, and Hideto Takahashi

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IL-15 sustains IL-7R-independent ILC2 and ILC3 development, Michelle L. Robinette, Jennifer K. Bando, Wilbur Song, Tyler K. Ulland, Susan Gilfillan, and Marco Colonna

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Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish, Jiakun Chen, Li Xia, Michael R. Bruchas, and Lilianna Solnica-Krezel

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Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years, Louis P. Dehner and et al

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Impact of age and race on outcomes of a program to prevent excess weight gain and disordered eating in adolescent girls, Natasha L. Burke, Lauren B. Shomaker, Sheila Brady, James C. Reynolds, Jami F. Young, Denise E. Wilfley, Tracy Sbrocco, Mark Stephens, Cara H. Olsen, Jack A. Yanovski, and Marian Tanofsky-Kraff

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Impact of insurance coverage on utilization of pre-exposure prophylaxis for HIV prevention, Rupa R. Patel, Leandro Mena, Amy Nunn, Timothy McBride, Laura C. Harrison, Catherine E. Oldenburg, Jingxia Liu, Kenneth H. Mayer, and Philip A. Chan

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Impact of shoulder sonography on clinical decision making, Michael V. Friedman, Travis J. Hillen, David V. Holland, James M. Essenberg, and Jennifer L. Demertzis

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Impaired barrier function and autoantibody generation in malnutrition enteropathy in Zambia, Phillip I. Tarr and et al

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Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome, Adil Bashir, Kathryn L. Bohnert, Dominic N. Reeds, Linda R. Peterson, Adam J. Bittel, Lisa de las Fuentes, Christina A. Pacak, Barry J. Byrne, and W. Todd Cade

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Implementation of objective PASC-derived taxon demarcation criteria for official classification of filoviruses, Gaya K. Amarasinghe and et al

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Improved survival after acute graft-versus-host disease diagnosis in the modern era, Robert J. Hayashi, Ravi Vig, and et al.

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Improving community ambulation after hip fracture: Protocol for a randomised, controlled trial, E Binder and et al

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Improving dialysis adherence for high risk patients using automated messaging: Proof of concept, A. Som, J. Groenendyk, T. An, K. Patel, R. Peters, G. Polites, and W. R. Ross

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Inadequate cancer screening: Lack of provider continuity is a greater obstacle than medical mistrust, Lauren D. Arnold, Martha M.O. McGilvray, J. Kyle Cooper, and Aimee S. James

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In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles, Erez Eitan, Valeria Tosti, Caitlin N. Suire, Edda Cava, Sean Berkowitz, Beatrice Bertozzi, Sophia M. Raefsky, Nicola Veronese, Ryan Spangler, Francesco Spelta, Maja Mustapic, Dimitrios Kapogiannis, Mark P. Mattson, and Luigi Fontana

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Increased breast tissue receptor activator of nuclear factor- κB ligand (RANKL) gene expression is associated with higher mammographic density in premenopausal women, Adetunji T. Toriola, Ha X. Dang, Ian S. Hagemann, Catherine M. Appleton, Graham A. Colditz, Jingqin Luo, and Christopher A. Maher

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Increased hazard of myocardial infarction with insulin‐provision therapy in actively smoking patients with diabetes mellitus and stable ischemic heart disease: The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial, Asrar A. Khan, Matthew J. Chung, Eric Novak, and David L. Brown

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Independent test of a model to predict severe acute esophagitis, Ellen X. Huang, Clifford G. Robinson, Alerson Molotievschi, Jeffrey D. Bradley, Joseph O. Deasy, and Jung Hun Oh

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Infections in hematopoietic cell transplant recipients: Results from the Organ Transplant Infection Project, a multicenter, prospective, cohort study, Mindy G. Schuster, Angela A. Cleveland, Erik R. Dubberke, Carol A. Kauffman, Robin K. Avery, Shahid Husain, David L. Paterson, Fernanda P. Silveira, Tom M. Chiller, Kaitlin Benedict, Kathleen Murphy, and Peter G. Pappas

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Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection, Amanda J. Lee, Branson Chen, Marianne V. Chew, Nicole G. Barra, Mira M. Shenouda, Tina Nham, Nico van Rooijen, Manel Jordana, Karen L. Mossman, Robert D. Schreiber, Matthias Mack, and Ali A. Ashkar

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Inflammatory osteolysis: A conspiracy against bone, Gabriel Mbalaviele, Deborah V. Novack, Georg Schett, and Steven L. Teitelbaum

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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication, Sharon K. Kuss-Duerkop, Juan Wang, Ignacio Mena, Kris White, Giorgi Metreveli, Ramanavelan Sakthivel, Miguel A. Mata, Raquel Munoz-Moreno, Xiang Chen, Florian Krammer, Michael S. Diamond, Zhijian J. Chen, Adolfo Garcia-Sastre, and Beatriz M. A. Fontoura

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Inherent limitations of probabilistic models for protein-DNA binding specificity, Shuxiang Ruan and Gary D. Stormo

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Inhibiting plasma kallikrein for hereditary angioedema prophylaxis, H. J. Wedner and et al

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Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice, Bin Cao, Lindsay A. Parnell, Michael S. Diamond, and Indira U. Mysorekar

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Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model, Charu Munjal, Anil G. Jegga, Amy M. Opoka, Ivan Stoilov, Russell A. Norris, Craig J. Thomas, J. Michael Smith, Robert P. Mecham, Giorgio M. Bressan, and Robert B. Hinton

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Inhibitory control of feature selectivity in an object motion sensitive circuit of the retina, Tahnbee Kim and Daniel Kerschensteiner

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Initial assessment of the infant with neonatal cholestasis--Is this biliary atresia?, Yumirle P. Turmelle and et al.

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Inpatient urine cultures are frequently performed without urinalysis or microscopy: Findings from a large academic medical center, Abigail L. Carson, Satish Munigala, Anthony J. Russo, Kathleen M. McMullen, Helen Wood, Ronald Jackups, and David K. Warren

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Insights into enterotoxigenic Escherichia coli diversity in Bangladesh utilizing genomic epidemiology, Jason W. Sahl, Jeticia R. Sistrunk, Nabilah Ibnat Baby, Yasmin Begum, Qingwei Luo, Alaullah Sheikh, Firdausi Qadri, James M. Fleckenstein, and David A. Rasko

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Insulin-stimulated lipid accumulation is inhibited by ROS-scavenging chemicals, but not by the Drp1 inhibitor Mdivi-1, Jung-Hak Kim, Sun-Ji Park, Bokyung Kim, Young-Geun Choe, and Dong-Seok Lee

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INTEGRATE-Vis: A tool for comprehensive gene fusion visualization, Jin Zhang, Teng Gao, and Christopher A. Maher

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Intensity modulated radiation therapy and surgery for management of retroperitoneal sarcomas: A single-institution experience, Pippa F. Cosper, Jeffrey Olsen, Todd DeWees, Brian A. Van Tine, William Hawkins, Jeff Michalski, and Imran Zoberi

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Intensity modulated radiation therapy for squamous cell carcinoma of the vulva: Treatment technique and outcomes, Yuan James Rao, Anupama Chundury, Julie K. Schwarz, Comron Hassanzadeh, Todd DeWees, Daniel Mullen, Matthew A. Powell, David G. Mutch, and Perry W. Grigsby

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Interaction between the FTO gene, body mass index and depression: Meta-analysis of 13701 individuals, John Rice and et al

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Interfacing peripheral nerve with macro-sieve electrodes following spinal cord injury, Nathan K. Birenbaum, Matthew R. MacEwan, and Wilson Z. Ray

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Interference of the T cell and antigen-presenting cell costimulatory pathway using CTLA4-Ig (abatacept) prevents Staphylococcal enterotoxin B pathology, Sarah J.C. Whitfield, Chris Taylor, Jane E. Risdall, Gareth D. Griffiths, James T.A. Jones, E. Diane Williamson, Sjoerd Rijpkema, Luisa Saraiva, Sandrine Vessillier, A. Christopher Green, and Alun J. Carter

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Interferon-lambda: A potent regulator of intestinal viral infections, Sanghyun Lee and Megan T. Baldridge

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Interferon regulatory factor 1 protects against chikungunya virus-induced immunopathology by restricting infection in muscle cells, Sharmila Nair, Subhajit Poddar, Raeann M. Shimak, and Michael S. Diamond

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Interplay of space radiation and microgravity in DNA damage and DNA damage response, María Moreno-Villanueva, Michael Wong, Tao Lu, Ye Zhang, and Honglu Wu

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Interrater and intrarater reliability of arthroscopic measurements of articular cartilage defects in the knee, David C. Flanigan, James L. Carey, Robert H. Brophy, William C. Graham, Alex C. DiBartola, David Hamilton, Haikady N. Nagaraja, and Christian Lattermann

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Interrater reliability of surveillance for ventilator-associated events and pneumonia, Meeta Prasad Kerlin, William E. Trick, Deverick J. Anderson, Hilary M. Babcock, Ebbing Lautenbach, Renaud Gueret, and Michael Klompas

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Intestinal epithelial-specific mTORC1 activation enhances intestinal adaptation after small bowel resection, Lauren Barron, Raphael C. Sun, Bola Aladegbami, Christopher R. Erwin, Brad W. Warner, and Jun Guo

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Intra- and inter-individual variability of microRNA levels in human cerebrospinal fluid: Critical implications for biomarker discovery, Hyejin Yoon, Krystal C. Belmonte, Tom Kasten, Randall Bateman, and Jungsu Kim

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Intraoperative electrocochleographic characteristics of auditory neuropathy spectrum disorder in cochlear implant subjects, William J. Riggs, Joseph P. Roche, Christopher K. Giardina, Michael S. Harris, Zachary J. Bastian, Tatyana E. Fontenot, Craig A. Buchman, Kevin D. Brown, Oliver F. Adunka, and Douglas C. Fitzpatrick

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Introduction to the Centers for Disease Control and Prevention and the Healthcare Infection Control Practices Advisory Committee guideline for the prevention of surgical site infections, Joseph S. Solomkin, John Mazuski, Joan C. Blanchard, Kamal M.F. Itani, Philip Ricks, E. Patchen Dellinger, George Allen, Rachel Kelz, Caroline E. Reinke, and Sandra I. Berrios-Torres

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Invasive fungal infections secondary to traumatic injury, Ryan Kronen, Stephen Y. Liang, Grant Bochicchio, Kelly Bochicchio, William G. Powderly, and Andrej Spec

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In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis, Shabaana A. Khader

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In vivo two-photon imaging of astrocytes in GFAP-GFP transgenic mice, Dongjun Guo, Jia Zou, Nicholas Rensing, and Michael Wong

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Isolated major aortopulmonary collateral as the sole pulmonary blood supply to an entire lung segment, Hannah S. Kim, R. Mark Grady, and Shabana Shahanavaz

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Isolation and characterization of synovial mesenchymal stem cell derived from hip joints: A comparative analysis with a matched control knee group, Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, and Akinori Sakai

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Is there a correlation between infection control performance and other hospital quality measures?, Lyndsay M. O'Hara, Daniel J. Morgan, Lisa Pineles, Shanshan Li, Carol Sulis, Jason Bowling, Marci Drees, Jesse T. Jacob, Deverick J. Anderson, David K. Warren, and Anthony D. Harris

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Is there an association between bone mineral density and mammographic density? A systematic review, Jong Min Lee, Susan Holley, Catherine Appleton, and Adetunji T. Toriola

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Keap1/Cullin3 modulates p62/SQSTM1 activity via UBA domain ubiquitination, YouJin Lee, Tsui-Fen Chou, Sara K. Pittman, Amy L. Keith, Babak Razani, and Conrad C. Weihl

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Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids, Vincenza Cifarelli, Nada A. Abumrad, and et al

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KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth, Corina Anastasaki, Sonika Dahiya, and David H. Gutmann

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Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells, Tuoen Liu, Kilannin Krysiak, Cara Lunn Shirai, Sanghyun Kim, Jin Shao, Matthew Ndonwi, and Matthew J. Walter

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Knockout of lysosomal enzyme-targeting gene causes abnormalities in mouse pup isolation calls, Terra D. Barnes and Timothy E. Holy

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Lack of MTTP activity in pluripotent stem cell-derived hepatocytes and cardiomyocytes abolishes apoB secretion and increases cell stress, Ali Javaheri and et al

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Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination, Amit Mogha, Kelly Monk, and et al.

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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass, Ingrid B. Borecki, Mary F. Feitosa, and et al