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Submissions from 2017

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Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report, Mary M. Mullen, Laura M. Divine, Ian S. Hagemann, Sheri Babb, and Matthew A. Powell

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Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA, Carlos A. Puyo, Daniela Peruzzi, Alexander Earhart, Evan Roller, Menelaos Karanikolas, Marin H. Kollef, Alexander S. Krupnick, Daniel Kreisel, Mohsen Ibrahim, and Andrew E. Gelman

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Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus, Debajit Saha, Wensheng Sun, Chao Li, Srinath Nizampatnam, William Padovano, Zhengdao Chen, Alex Chen, Ege Altan, Ray Lo, Dennis L. Barbour, and Baranidharan Raman

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Engineering of GlcNAc-1-phosphotransferase for production of highly phosphorylated lysosomal enzymes for enzyme replacement therapy, Lin Liu, Wang-Sik Lee, Balraj Doray, and Stuart Kornfeld

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Enhanced antimicrobial de-escalation for pneumonia in mechanically ventilated patients: A cross-over study, Tracy Trupka, Kristen Fisher, Scott T. Micek, Paul Juang, and Marin H. Kollef

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Enhancing evidence-based diabetes and chronic disease control among local health departments: A multi-phase dissemination study with a stepped-wedge cluster randomized trial component, Renee G. Parks, Rachel G. Tabak, Peg Allen, Elizabeth A. Baker, Katherine A. Stamatakis, Allison R. Poehler, Yan Yan, Marshall H. Chin, Jenine K. Harris, Maureen Dobbins, and Ross C. Brownson

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Enrichment and molecular analysis of breast cancer disseminated tumor cells from bone marrow using microfiltration, Sreeraj G. Pillai, Peixuan Zhu, Chidananda M. Siddappa, Daniel L. Adams, Shuhong Li, Olga V. Makarova, Pete Amstutz, Ryan Nunley, Cha-Mei Tang, Mark A. Watson, and Rebecca L. Aft

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Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria, Shannon I. Ohlemacher, Daryl E. Giblin, D. Andre Avignon, Ann E. Stapleton, Barbara W. Trautner, and Jeffrey P. Henderson

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Environmental enteric dysfunction and the fecal microbiota in malawian children, M. Isabel Ordiz, Kevin Stephenson, Sophia Agapova, Kristine M. Wylie, Ken Maleta, John Martin, Indi Trehan, Washington University School of Medicine in St. Louis, and Mark J. Manary

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Environmental enteric dysfunction is associated with carnitine deficiency and altered fatty acid oxidation, Richard D. Semba, Indi Trehan, Ximin Li, Ruin Moaddel, M. Isabel Ordiz, Kenneth M. Maleta, Klaus Kraemer, Michelle Shardell, Luigi Ferrucci, and Mark Manary

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Epidemiology and outcomes of vertebral artery injury in 16582 cervical spine surgery patients: An AOSpine North America multicenter study, Wilson Z. Ray and et al.

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Epidemiology of Cryptococcosis and Cryptococcal Meningitis in a large retrospective cohort of patients after solid organ transplantation, Ige A. George, Carlos A. Santos, Margaret A. Olsen, and William G. Powderly

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Epidermal growth factor receptors containing a single tyrosine in their C-terminal tail bind different effector molecules and are signaling-competent, Kamaldeep Gill, Jennifer L. Macdonald-Obermann, and Linda J. Pike

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Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity, Vikrant Borse, Raheem FH Al Aameri, Kelly Sheehan, Sandeep Sheth, Tejbeer Kaur, Debashree Mukherjea, Srinivasan Tupal, Michelle Lowy, Sumana Ghosh, Asmita Dhukhwa, Puspanjali Bhatta, Leonard P. Rybak, and Vickram Ramkumar

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Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine, Bola Aladegbami, Lauren Barron, James Bao, Jason Colasanti, Christopher R. Erwin, Brad W. Warner, and Jun Guo

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Epithelial chloride transport by CFTR requires TMEM16A, Roberta Benedetto, Jiraporn Ousingsawat, Podchanart Wanitchakool, Yong Zhang, Michael J. Holtzman, Margarida Amaral, Jason R. Rock, Rainer Schreiber, and Karl Kunzelmann

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EpxMedTracking: Feasibility evaluation of an SMS-based medication adherence tracking system in community practice, Christopher Tricarico, Robert Peters, Avik Som, Kavon Javaherian, and Will Ross

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Esophageal perforation following anterior cervical spine surgery: Case report and review of the literature, Michael P. Kelly, Jacob M. Buchowski, Wilson Z. Ray, Colleen M. Peters, Jin Young Kim, and et al.

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Establishing prevalence in rare neuromuscular diseases: A lesson from congenital myopathies, Ahmed K. Bamaga and Conrad C. Weihl

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Esterase mutation is a mechanism of resistance to antimalarial compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, and Daniel E. Goldberg

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Estimating correlation between multivariate longitudinal data in the presence of heterogeneity, Feng Gao, J. Philip Miller, Chengjie Xiong, Jingqin Luo, Julia A. Beiser, Ling Chen, and Mae O. Gordon

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Estimating error models for whole genome sequencing using mixtures of Dirichlet-multinomial distributions, Steven H. Wu, Rachel S. Schwartz, David J. Winter, Donald F. Conrad, and Reed A. Cartwright

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ETV2/ER71 regulates hematopoietic regeneration by promoting hematopoietic stem cell proliferation, Can-Xin Xu, Tae-Jin Lee, Nagisa Sakurai, Karen Krchma, Fang Liu, Daofeng Li, Ting Wang, and Kyunghee Choi

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Evaluation of 64Cu-based radiopharmaceuticals that target Aβ peptide aggregates as diagnostic tools for Alzheimer’s disease, Nilantha Bandara, Anuj K. Sharma, Stephanie Krieger, Jason W. Schultz, Byung Hee Han, Buck E. Rogers, and Liviu M. Mirica

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Evaluation of attenuated tumor antigens and the implications for peptide-based cancer vaccine development, J. S. Berry, T. J. Vreeland, D. F. Hale, D. O. Jackson, A. F. Trappey, J. M. Greene, M. O. Hardin, G. S. Herbert, G. T. Clifton, and G. E. Peoples

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Evaluation of correlation between pretest probability for Clostridium difficile infection and Clostridium difficile enzyme immunoassay results, Jennie H. Kwon, Kimberly A. Reske, Tiffany Hink, Carey-Ann D. Burnham, and Erik R. Dubberke

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Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly, Tina Graves-Lindsay, Derek Albracht, Robert S. Fulton, Milinn Kremitzki, Vincent Magrini, Chris Markovic, Sean McGrath, Karyn Meltz Steinberg, Richard K. Wilson, and et al

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Evaluation of the 2015 AGA guidelines on pancreatic cystic neoplasms in a large surgically confirmed multicenter cohort, Srinivas Gaddam, Vladimir M. Kushnir, Daniel Mullady, Dayna S. Early, and et al.

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Evans syndrome complicated by intratubular hemoglobin cast nephropathy, Ivan Gonzalez, Rehan Rais, Joseph P. Gaut, and Louis P. Dehner

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Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions, Vasilios Kalas, Jerome S. Pinkner, Thomas J. Hannan, Michael E. Hibbing, Karen W. Dodson, Alex S. Holehouse, Hao Zhang, Niraj H. Tolia, Michael L. Gross, Rohit V. Pappu, James Janetka, and Scott J. Hultgren

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Evolution, development and function of vertebrate cone oil droplets, Matthew B. Toomey and Joseph C. Corbo

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Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes, Charles K. Kaufman and et al

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Exacerbated leishmaniasis caused by a viral endosymbiont can be prevented by immunization with Its viral capsid, Patrick Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzxchneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Nicolas Fasel, and Catherine Ronet

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Examining summer laboratory research apprenticeships for high school students as a factor in entry to MD/PhD programs at matriculation, Robert H. Tai, Xiaoqing Kong, Claire E. Mitchell, Katherine P. Dabney, Daniel M. Read, Donna B. Jeffe, Dorothy A. Andriole, and Heather D. Wathington

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Exploitation of a newly-identified entry pathway into the malaria parasite-infected erythrocyte to inhibit parasite egress, Svetlana Glushakova, Brad L. Busse, Matthias Garten, Josh R. Beck, Rick M. Fairhurst, Daniel E. Goldberg, and Joshua Zimmerberg

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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis, Ismail Sergin, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl J. Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn B. Holloway, Paul S. Micevych, Ali Javaheri, Jan R. Crowley, Andrea Ballabio, Joel D. Schilling, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Mohamed A. Zayed, and Babak Razani

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Exposure to maternal obesogenic diet worsens some but not all pre-cancer phenotypes in a murine genetic model of prostate cancer, Theresa Okeyo-Owuor, Emily Benesh, Scott Bibbey, Michaela Reid, Jacques Halabi, Siobhan Sutcliffe, and Kelle Moley

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Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells, Christopher H. Emfinger, Alecia Welscher, Zihan Yan, Yixi Wang, Hannah Conway, Jennifer B. Moss, Larry G. Moss, Maria S. Remedi, and Colin G. Nichols

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ExpressionDB: An open source platform for distributing genome-scale datasets, Laura D. Hughes, Scott A. Lewis, and Michael E. Hughes

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Expression of CD226 is associated to but not required for NK cell education, Arnika K. Wagner, Nadir Kadri, Johanna Snäll, Petter Brodin, Susan Gilfillan, Marco Colonna, Günter Bernhardt, Petter Höglund, Klas Kärre, and Benedict J. Chambers

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Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus, Megan T. Baldridge, Sanghyun Lee, Judy J. Brown, Nicole McAllister, Kelly Urbanek, Terence S. Dermody, Timothy J. Nice, and Herbert W. Virgin

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Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement, Claire E. Meyer, Phillip N. Key, Toby Zhu, Mark Shabsovich, Ann Ni, and Sandeep K. Tripathy

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External beam radiation therapy or brachytherapy with or without short-course neoadjuvant androgen deprivation therapy: Results of a multicenter, prospective study of quality of life, Hiram A. Gay, Jiangxia Liu, Ningying Wu, Jeff M. Michalski, and et al

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Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms, Stefanie Kennon-McGill and Mitchell R. McGill

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Face processing in adolescents with positive and negative threat bias, C.M. Sylvester, S.E. Petersen, J.L. Luby, and D.M. Barch

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Familial screening for left-sided congenital heart disease: What is the evidence? What is the cost?, Daniel J. Perry, Connor R. Mullen, Horacio G. Carvajal, Anoop K. Brar, and Pirooz Eghtesady

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Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy, Terence T.W. Wong, Ruiying Zhang, Pengfei Hai, Chi Zhang, Miguel A. Pleitez, Rebecca L. Aft, Deborah V. Novack, and Lihong V. Wang

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Female hormonal exposures and neuromyelitis optica symptom onset in a multicenter study, Enrique Alvarez, Anne H. Cross, and et al

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FGFR2 amplification in colorectal adenocarcinoma, Jamal H. Carter, Catherine E. Cottrell, Samantha N. McNulty, Katinka A. Vigh-Conrad, Stephen Lamp, Jonathan W. Heusel, and Eric J. Duncavage

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Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients, Csaba Konrad, Hibiki Kawamata, Kirsten G. Bredvik, Andrea J. Arreguin, Steven A. Cajamarca, Jonathan C. Hupf, John M. Ravits, Timothy M. Miller, Nicholas J. Maragakis, Chadwick M. Hales, Jonathan D. Glass, Steven Gross, Hiroshi Mitsumoto, and Giovanni Manfredi

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Fibroblast growth factor receptor 2 (FGFR2) is required for meibomian gland homeostasis in the adult mouse, Lixing W. Reneker, LanLan Wang, Rebecca T. Irlmeier, and Andrew J. W. Huang

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Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries, Carmen M. Halabi, Thomas J. Broekelmann, Michelle Lin, Vivian S. Lee, Mon-Li Chu, and Robert P. Mecham

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First-in-man evaluation of 124I-PGN650: A PET tracer for detecting phosphatidylserine as a biomarker of the solid tumor microenvironment, Richard Laforest, Farrokh Dehdashti, Yongjian Liu, Jennifer Frye, Sarah Frye, Hannah Luehmann, Deborah Sultan, Joseph S. Shan, Bruce D. Freimark, and Barry A. Siegel

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Fluorescence lifetime imaging ophthalmoscopy, Chantal Dysli, Sebastian Wolf, Mikhail Y. Berezin, Lydia Sauer, Martin Hammer, and Martin S. Zinkernagel

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Follow-up of prostatectomy versus observation for early prostate cancer, Timothy J. Wilt, Karen M. Jones, Michael J. Barry, Gerald L. Andriole, Daniel Culkin, Thomas Wheeler, William J. Aronson, and Michael K. Brawer

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Force‐sensing catheters during pediatric radiofrequency ablation: The FEDERATION Study, Aarti S. Dalal, Hoang H. Nguyen, Tammy Bowman, George F. Van Hare, and Jennifer N. Avari Silva

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Frequency-specific electrophysiologic correlates of resting state fMRI networks, Carl D. Hacker, Abraham Z. Snyder, Mrinal Pahwa, Maurizio Corbetta, and Eric C. Leuthardt

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From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood [version 1; referees: 3 approved], Andrew B. Janowski and Jason G. Newland

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Frontotemporal lobar degeneration and social behaviour: Dissociation between the knowledge of its consequences and its conceptual meaning, Roland Zahn, Sophie Green, Helen Beaumont, Alistair Burns, Jorge Moll, Diana Caine, Alexander Gerhard, Paul Hoffman, Benjamin Shaw, Jordan Grafman, and Matthew A. Lambon Ralph

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Fructose in breast milk is positively associated with infant body composition at 6 months of age, Michael I. Goran, Ashley A. Martin, Tanya L. Alderete, Hideji Fujiwara, and David A. Fields

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Functional cis-regulatory modules encoded by mouse-specific endogenous retrovirus, Vasavi Sundaram, Mayank N.K. Choudhary, Erica Pehrsson, Xiaoyun Xing, Christopher Fiore, Manishi Pandey, Brett Maricque, Methma Udawatta, Duc Ngo, Yujie Chen, Asia Paguntalan, Tammy Ray, Ava Hughes, Barak A. Cohen, and Ting Wang

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Functional connectivity of cognitive brain networks in schizophrenia during a working memory task, Douglass Godwin, Andrew Ji, Sridhar Kandala, and Daniel Mamah

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Functional connectivity structure of cortical calcium dynamics in anesthetized and awake mice, Patrick W. Wright, Lindsey M. Brier, Adam Q. Bauer, Grant A. Baxter, Andrew W. Kraft, Matthew D. Reisman, Annie R. Bice, Abraham Z. Snyder, Jin-Moo Lee, and Joseph P. Culver

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Functional network changes and cognitive control in schizophrenia, Kimberly L. Ray, Tyler A. Lesh, Amber M. Howell, Taylor P. Salo, J. Daniel Ragland, Angus W. MacDonald, James M. Gold, Steven M. Silverstein, Deana M. Barch, and Cameron S. Carter

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Functional outcomes of childhood selective dorsal rhizotomy 20 to 28 years later, T. S. Park, Jenny L. Liu, Caleb Edwards, Deanna M. Walter, and Matthew B. Dobbs

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Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex, Syna Kuriakose Gift, Daniel P. Leaman, Lei Zhang, Arthur S. Kim, and Michael B. Zwick

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Fungal infections increase the mortality rate three-fold in necrotizing soft-tissue infections, Christopher B. Horn, Brendan M. Wesp, Nicholas B. Fiore, Rohit K. Rasane, Marlon Torres, Isaiah R. Turnbull, Obeid N. Ilahi, Laurie J. Punch, and Grant V. Bochicchio

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GABA-B controls persistent Na+ current and coupled Na+-activated K+ current, Ping Li, Richard Stewart, Alice Butler, Ana Laura Gonzalez-Cota, Steve Harmon, and Lawrence Salkoff

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GATA3 is a sensitive marker for primary genital extramammary paget disease: An immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15, Dengfeng Cao and et al

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Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors, Savita Sankar, Ethan Patterson, Emily M. Lewis, Laura E. Waller, Caili Tong, Joshua Dearborn, David Wozniak, Joshua B. Rubin, and Kristen L. Kroll

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Gene expression in Leishmania is regulated predominantly by gene dosage, Stefano A. Iantorno, Caroline Durrant, Asis Khan, Mandy J. Sanders, Stephen M. Beverley, Wesley C. Warren, Matthew Berriman, David L. Sacks, James A. Cotton Wellcome Trust Sanger Institute, and Michael E. Grigg

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Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons, Joseph D. Dougherty

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Generation and characterization of α9 and α10 nicotinic acetylcholine receptor subunit knockout mice on a C57BL/6J background, Barbara J. Morley, David F. Dolan, Kevin K. Ohlemiller, and Dwayne D. Simmons

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Genetic association of MMP10, MMP14, and MMP16 with dental caries, D. D. Lewis, J. R. Shaffer, E. Feingold, M. Cooper, M. M. Vanyukov, B. S. Maher, R. L. Slayton, M. C. Willing, S. E. Reis, D. W. McNeil, R. J. Crout, R. J. Weyant, S. M. Levy, A. R. Vieira, and M. L. Marazita

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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia, C. Robert Cloninger, Dragan M. Svrakic, and et al

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Genetic effects influencing risk for major depressive disorder in China and Europe, A. C. Heath, J. P. Rice, and et al

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Genetic loci associated with heart rate variability and their effects on cardiac disease risk, Phyllis K. Stein and et al

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Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania, Hongjie Guo, Natalia M. Novozhilova, Giulia Bandini, Salvatore J. Turco, Michael A. J. Ferguson, and Stephen M. Beverly

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Genetic variation and expression changes associated with molybdate resistance from a glutathione producing wine strain of Saccharomyces cerevisiae, Francesco Mezzetti, Justin C. Fay, Paolo Guidici, and Luciana De Vero

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Genetic variation at 16q24.2 is associated with small vessel stroke, Jin-Moo Lee, Laura Heitsch, and et al

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Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs, Jonathan M. Brunger, Ananya Zutshi, Vincent P. Willard, Charles A. Gersbach, and Farshid Guilak

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Genome sequence of Christensenella minuta DSM 22607T, Bruce A. Rosa, Kymberlie Hallsworth-Pepin, John Martin, Aye Wollam, and Makedonka Mitreva

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Genome sequence of enterovirus D68 from St. Louis, Missouri, USA, 2016, Kristine M. Wylie, Todd N. Wylie, and Gregory A. Storch

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Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human Sennetsu fevers, Samantha N. McNulty, Bruce A. Rosa, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Peter U. Fischer, Makedonka Mitreva, and et al.

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GenomeVIP: A cloud platform for genomic variant discovery and interpretation, R. Jay Mashl, Adam D. Scott, Kuan-lin Huang, Matthew A. Wyczalkowski, Christopher J. Yoon, Beifang Niu, Erin DeNardo, Venkata D. Yellapantula, Robert E. Handsaker, Ken Chen, Daniel C. Koboldt, Kai Ye, David Fenyö, Benjamin J. Raphael, Michael C. Wendl, and Li Ding

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Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts, Mary K. Wojczynski, Ingrid B. Borecki, and et al.

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Genome-wide association study of male sexual orientation, Dragan M. Svrakic, C. Robert Cloninger, and et al

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Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism, Alison M. Goate, Carlos Cruchaga, and et al

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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits, Yun Ju Sung, D.C. Rao, Treva Rice, Andrew C. Heath, Pamela A.F. Madden, Mary F. Feitosa, Llilda Barata, Jacek Czajkowski, Ingrid B. Borecki, and et al

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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults, Mary F. Feitosa, Llilda Barata, Ingrid B. Borecki, and et al.

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Genome-wide screen for genes involved in Caenorhabditis elegans developmentally timed sleep, Huiyan Huang, Chen-Tseh Zhu, Lukas L. Skuja, Dustin J. Hayden, and Anne C. Hart

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Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast, Christopher A. Maher and et al

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Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta, Young-Jun Choi, Stewart A. Bisset, Stephen R. Doyle, Kymberlie Hallsworth-Pepin, John Martin, Warwick N. Grant, and Makedonka Mitreva

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Genomic landscape of high-grade meningiomas, Ekaterina Esaulova, Maksym Artyomov, Gavin P. Dunn, and et al

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Genomic profile of human meningioma cell lines, Yu Mei, Wenya Linda Bi, Noah F. Greenwald, Nathalie Y. Agar, Rameen Beroukhim, Gavin P. Dunn, and Ian F. Dunn

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Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study, Jean S. Wang, Ilke Nalbantoglu, and et al.

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Germ-line and somatic EPHA2 coding variants in lens aging and cataract, Thomas M. Bennett, Oussama M'Hamdi, J. Fielding Hejtmancik, and Alan Shiels

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Giant cystic pheochromocytoma with low risk of malignancy: A case report and literature teview, Ravi Maharaj, Sangeeta Parbhu, Wesley Ramcharan, Shanta Baijoo, Wesley Greaves, Dave Harnanan, and Wayne A. Warner

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Gli1 identifies osteogenic progenitors for bone formation and fracture repair, Yu Shi, Guangxu He, Wen-Chih Lee, Jennifer A. McKenzie, Matthew J. Silva, and Fanxin Long

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Glucocorticoid receptor action in metabolic and neuronal function [version 1; referees: 3 approved], Michael J. Garabedian, Charles A. Harris, and Freddy Jeanneteau