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Submissions from 2010

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Identification of YsrT and evidence that YsrRST constitute a unique phosphorelay system in Yersinia enterocolitica, Kimberly A. Walker, Markus W. Obrist, Shirly Mildiner-Earley, and Virginia L. Miller

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Image-based calibration of a deformable mirror in wide-field microscopy, Diwakar Turaga and Timothy E. Holy

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Images in clinical medicine. Meckel's diverticulum, Brian T. Bucher and Martin S. Keller

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Immunotherapy for sepsis - A new approach against an ancient foe, Richard S. Hotchkiss and Steven Opal

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Improved survival with ipilimumab in patients with metastatic melanoma, Gerald P. Linette and et al

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Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study, Marya D. Zilberberg, Marin H. Kollef, Heather Arnold, Andrew Labelle, Scott T. Micek, Smita Kothari, and Andrew F. Shorr

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In-center hemodialysis six times per week versus three times per week, Brent Miller and et al

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Individual and setting level predictors of the implementation of a skin cancer prevention program: a multilevel analysis, Borsika A. Rabin, Eric Nehl, Tom Elliot, Anjali D. Deshpande, Ross C. Brownson, and Karen Glanz

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Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice, Ildiko R. Dunay, Anja Fuchs, and L. David Sibley

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Influenza vaccination among healthcare workers: Ten-year experience of a large healthcare organization, Cristina Ajenjo, Keith F. Woeltje, Hilary M. Babcock, Nancy Gemeinhart, Marilyn Jones, and Victoria J. Fraser

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Integrated genomics of susceptibility to alkylator-induced leukemia in mice, Patrick Cahan and Timothy A. Graubert

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Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons, Aaron J. Norris, Nicholas C. Foeger, and Jeanne M. Nerbonne

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Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through γδ T-cell IL-17 production in a murine model of sepsis, Kevin R. Kasten, Priya S. Prakash, Jacqueline Unsinger, Holly S. Goetzman, Lisa G. England, Cindy M. Cave, Aaron P. Seitz, Cristina N. Mazuski, Tony T. Zhou, Michel Morre, Richard S. Hotchkiss, David A. Hildeman, and Charles C. Caldwell

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In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: Early gene expression profiling reveals possible drug target in AML, Anmaar M. Abdul-Nabi, Enas R. Yassin, Nobish Varghese, Hrishikesh Deshmukh, and Nabeel R. Yaseen

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IPS-1 is essential for the control of West Nile virus infection and immunity, Mehul S. Suthar, Daphne Y. Ma, Sunil Thomas, Jennifer M. Lund, Nu Zhang, Stephane Daffis, Alexander Y. Rudensky, Michael J. Bevan, Edward A. Clark, Murali-Krishna Kaja, Michael S. Diamond, and Michael Gale Jr.

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Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase, Sarah M. Brown, Rajendra Upadhya, James D. Shoemaker, and Jennifer K. Lodge

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Is transcription factor binding site turnover a sufficient explanation for cis-regulatory sequence divergence?, Sandeep Venkataram and Justin C. Fay

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It's not easy being green: The viridans group streptococci, with a focus on pediatric clinical manifestations, Christpher D. Doern and Carey-Ann D. Burnham

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Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern, Deborah E. Dobson, Shaden Kamhawi, Phillip Lawyer, Salvatore J. Turco, Stephen M. Beverley, and David L. Sacks

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Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification, Scott J. Balsitis, Katherine L. Williams, Ruben Lachica, Diana Flores, Jennifer L. Kyle, Erin Mehlhop, Syd Johnson, Michael S. Diamond, P. Robert Beatty, and Eva Harris

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Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice, Chunxiu Hu, Miriam Hoene, Xinjie Zhao, Hans U. Haring, Erwin Schleicher, Rainer Lehmann, Xianlin Han, Guowang Xu, and Cora Weigert

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Lipids driving protein structure? Evolutionary adaptations in Kir channels, Nazzareno D'Avanzo, Wayland W.L. Chang, Shizhen Wang, Decha Enkvetchakul, and Colin G. Nichols

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Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors, Hyun Bae Kim, Anil Kumar, Lifu Wang, Guang-Hui Liu, Susan R. Keller, John C. Lawrence Jr., Brian N. Finck, and Thurl E. Harris

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Lisdexamfetamine dimesylate: A prodrug stimulant for the treatment of ADHD in children and adults, Greg W. Mattingly

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Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1, Harley T. Kurata, Emily A. Zhu, and Colin G. Nichols

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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes, Kei Fujimoto, Eric L. Ford, Hung Tran, Burton M. Wice, Seth D. Crosby, Gerald W. Dorn II, and Kenneth S. Polonsky

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Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis, Jochen K. Lennerz, Jonathan B. Hurov, Lynn S. White, Katherine T. Lewandowski, Julie L. Prior, G. James Planer, Robert W. Gereau IV, David Piwnica-Worms, Robert E. Schmidt, and Helen Piwnica-Worms

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Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking, Rodrigo A. Fuentealba, Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee, Mary Jo LaDu, and Guojun Bu

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Macaque parieto-insular vestibular cortex: Responses to self-motion and optic flow, Aihua Chen, Gregory C. DeAngelis, and Dora E. Angelaki

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Magnesium induces neuronal apoptosis by suppressing excitability, W. H. Dribben, L. N. Eisenman, and S. Mennerick

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Major depression and the metabolic syndrome, Debra L. Foley, Katherine I. Morley, Pamela A.F. Madden, Andrew C. Heath, John B. Whitfield, and Nicholas G. Martin

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Management of patients with advanced non-small cell lung cancer: role of gefitinib, Vamsidhar Velcheti, Daniel Morgensztern, and Ramaswamy Govindan

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Massively parallel sequencing and analysis of the Necator americanus transcriptome, Cinzia Cantacessi, Makedonka Mitreva, Aaron R. Jex, Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Maria A. Doyle, Stuart A. Ralph, Elida M. Rabelo, Shoba Ranganathan, Paul W. Sternberg, Alex Loukas, and Robin B. Gasser

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Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia, Zhifu Xiang, Hui Luo, Jacqueline E. Payton, Jennifer Cain, Timothy J. Ley, Joseph T. Opferman, and Michael H. Tomasson

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Measuring the impact of public health policy, Ross C. Brownson, Rachel Seiler, and Amy A. Eyler

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Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure, Gerald W. Dorn II

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Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo, Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, and Marco Colonna

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Metabolic flexibility revealed in the genome of the cyst-forming α-1 proteobacterium Rhodospirillum centenum, Yih-Kuang Lu, Jeremiah Marden, Mira Han, Wesley D. Swingley, Stephen D. Mastrian, Sugata Roy Chowdhury, Jicheng Hao, Tamer Helmy, Sun Kim, Ahmet A. Kurdoglu, Heather J. Matthies, David Rollo, Paul Stothard, Robert E. Blankenship, Carl E. Bauer, and Jeffrey W. Touchman

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MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment, Julie M. Elliott, Joseph A. Wahle, and Wayne M. Yokoyama

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Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice, Qiang Wang, Antonina I. Frolova, Scott Purcell, Katie Adastra, Erica Schoeller, Maggie M. Chi, Tim Schedl, and Kelle H. Moley

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Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex, Albert Misko, Siriui Jiang, Iga Wegorzewska, Jeffrey Milbrandt, and Robert H. Baloh

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mmunohistological studies on neoplasms of female and male Onchocerca volvulus: Filarial origin and absence of Wolbachia from tumor cells, N. W. Brattig, A. Hoerauf, Peter U. Fischer, E. Liebau, C. Bandi, A. Debrah, M. Büttner, and W. Büttner

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Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder, Richard C. McEachin, Nancy L. Saccone, Scott F. Saccone, Yelena D. Kleyman-Smith, Tiara Kar, Rajesh K. Kare, Alex S. Ade, Maureen A. Sartor, James D. Cavalcoli, and Melvin G. McInnis

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MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair, Girdhar G. Sharma, Sairei So, Arun Gupta, Rakesh Kumar, Christelle Cayrou, Nikita Avvakumov, Utpal Bhadra, Raj K. Pandita, Matthew H. Porteus, David J. Chen, Jacques Cote, and Tej K. Pandita

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Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy, Naomi Gronich, Azad Kumar, Yuwei Zhang, Igor R. Efimov, and Nikolai M. Soldatov

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More than Tuskegee: Understanding mistrust about research participation, Darcell P. Scharff, Katherine J. Mathews, Pamela Jackson, Jonathan Hoffsuemmer, Emeobong Martin, and Dorothy Edwards

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Multicenter study of clinical performance of the 3M rapid detection RSV test, Christine C. Ginocchio, Ella Swierkosz, Alexander J. McAdam, Mario Marcon, Gregory A. Storch, Alexandra Valsamakis, Stefan Juretschko, José Romero, and Belinda Yen-Lieberman

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Multiple distinct small RNAs originate from the same microRNA precursors, Weixiong Zhang, Shang Gao, Xuefeng Zhou, Jing Xia, Padmanabhan Chellappan, Xiang Zhou, Xiaoming Zhang, and Hailing Jin

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD, Nancy L. Saccone, Robert C. Culverhouse, Tae-Hwi Schwantes-An, Lingwei Sun, Andrew C. Heath, Michele L. Pergadia, John P. Rice, Jen C. Wang, Pamela A.F Madden, Laura J. Bierut, and et al.

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Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex, Mark D. Gonzalez, Esra A. Akbay, Dana Boyd, and Jon Beckwith

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Multiple pathways of inhibition shape bipolar cell responses in the retina, Erika D. Eggers and Peter D. Lukasiewicz

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Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis, Shannon McNulty, William Bornmann, Jill Schriewer, Chas Werner, Scott K. Smith, Victoria A. Olson, Inger K. Damon, R. Mark Buller, John Heuser, and Daniel Kalman

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Multiplexed echo planar imaging for sub-second whole brain fMRI and fast diffusion imaging, David A. Feinberg, Steen Moeller, Stephen M. Smith, Edward Auerbach, Sudhir Ramanna, Matt F. Glasser, Karla L. Miller, Kamil Ugurbil, and Essa Yacoub

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Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration, Richard T. Robinson, Shabaana A. Khader, Cynthia A. Martino, Jeffrey J. Fountain, Maria Teixeira-Coelho, John E. Pearl, Stephen T. Smiley, Gary M. Winslow, David L. Woodland, Michael J. Walter, Jose R. Conejo-Garcia, Ueli Gubler, and Andrea M. Cooper

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Neighborhood conditions, diabetes, and risk of lower-body functional limitations among middle-aged African Americans: A cohort study, Mario Schootman, Elena M. Andresen, Fredric D. Wolinsky, J Philip Miller, Yan Yan, and Douglas K. Miller

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Neoadjuvant endocrine therapy in primary breast cancer: Indications and use as a research tool, Yeehong Chia, M. J. Ellis, and Cynthia Ma

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Neonatal intravenous injection of a gammaretroviral vector has a low incidence of tumor induction in mice, Mindy Tittiger, Xiuxui Ma, Lingfei Xu, and Katherine P. Ponder

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Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner, Da Yong Lee, Tu-Hsueh Yeh, Ryan J. Emnett, Crystal R. White, and David H. Gutmann

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Next-generation sequencing identifies the natural killer cell microRNA transcriptome, Todd A. Fehniger, Todd Wylie, Elizabeth Germino, Jeffrey W. Leong, Vincent J. Magrini, Sunita Koul, Catherine R. Keppel, Stephanie E. Schneider, Daniel C. Koboldt, Ryan P. Sullivan, Michael E. Heinz, Seth D. Crosby, Rakesh Nagarajan, Giridharan Ramsingh, Daniel C. Link, Timothy J. Ley, and Elaine R. Mardis

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Nicotine withdrawal symptoms in adolescent and adult twins, Michele L. Pergadia, Arpana Agrawal, Andrew C. Heath, Nicholas G. Martin, Kathleen K. Bucholz, and Pamela A.F. Madden

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NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis, Chang Yang, Kathleen McCoy, Jennifer L. Davis, Marc Schmidt-Supprian, Yoshiteru Sasaki, Roberta Faccio, and Deborah Veis Novack

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No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice, Haiyan Shen, Jonathan I. Matsui, Debin Lei, Lirong Han, Kevin K. Ohlemiller, and Jianxin Bao

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Novel screening agar for detection of vancomycin-nonsusceptible Staphylococcus aureus, Carey-Ann D. Burnham, Carol J. Weber, and W. Michael Dunne Jr.

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Novel venom gene discovery in the platypus, Camilla M. Whittington, Anthony T. Papenfuss, Devin P. Locke, Elaine R. Mardis, Richard K. Wilson, Sahar Abubucker, Makedonka Mitreva, Emily SW Wong, Arthur L. Hsu, Philip W. Kuchel, Katherine Belov, and Wesley C. Warren

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Nurturing the genome: A-type lamins preserve genomic stability, Ignacio Gonzalez-Suarez and Susana Gonzalo

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Open access series of imaging studies: Longitudinal MRI data in nondemented and demented older adults, Daniel S. Marcus, Anthony F. Fotenos, John G. Csernansky, John C. Morris, and Randy L. Buckner

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Optimal use of beta-blockers in high-risk hypertension: a guide to dosing equivalence, Janet B. McGill

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Organogenetic tolerance, Marc R. Hammerman

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Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice, Sanjay Jain, Amanda Knoten, Masato Hoshi, Hongtao Wang, Bhupinder Vohra, Robert O. Heuckeroth, and Jeffrey Milbrandt

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Osseous metaplasia late in the course of nephrogenic systemic fibrosis, David R. Berk, Alicia Miller, Debra Scarlett, Franz J. Wippold II, Susan J. Bayliss, and Dongsi Lu

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p38δ mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis, Tatiana Efimova

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p97/VCP at the intersection of the autophagy and the ubiquitin proteasome system, Jeong-Sun Ju and Conrad C. Weihl

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Parallel input channels to mouse primary visual cortex, Enquan Gao, Gregory C. DeAngelis, and Andreas Burkhalter

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Parental depression and offspring psychopathology: A Children of Twins study, A. L. Singh, B. M. D'Onofrio, W. S. Slutske, E. Turkheimer, R. E. Emery, K. P. Harden, A. C. Heath, P. A F Madden, D. J. Statham, and N. G. Martin

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Perceptions of HIV risk among monogamous wives of alcoholic men in South India: A qualitative study, Deepthi S. Varma, Prabha S. Chandra, Catina Callahan, Wendy Reich, and Linda B. Cottler

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Periorbital edema secondary to imatinib mesylate, Collin M. McClelland, George J. Harocopos, and Philip L. Custer

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Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells, Brian T. Edelson, Wumesh KC, Richard Juang, Masako Kohyama, Loralyn A. Benoit, Paul A. Klekotka, Clara Moon, Jörn C. Albring, Wataru Ise, Drew G. Michael, Deepta Bhattacharya, Thaddeus S. Stappenbeck, Michael J. Holtzman, Sun-Sang J. Sung, Theresa L. Murphy, Kai Hildner, and Kenneth M. Murphy

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Perspectives on: Molecular dynamics and computational methods Multi-scale electrophysiology modeling: from atom to organ, Jonathan R. Silva and Yoram Rudy

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Phospholipase C gamma 2 Is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells, Viviana Cremasco, Elisa Benasciutti, Marina Cella, Marina Kisseleva, Monica Croke, and Roberta Faccio

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Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks, Emma Bolderson, Nozomi Tomimatsu, Derek J. Richard, Didier Boucher, Rakesh Kumar, Tej K. Pandita, Sandeep Burma, and Kum K. Khanna

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Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii, Tobias Steinfeldt, Stephanie Konen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L. David Sibley, Julia P. Hunn, and Jonathan C. Howard

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Physical activity in US Blacks: a systematic review and critical examination of self-report instruments, Kathleen Y. Wolin, Casey Fagin, Nneka Ufere, Hallie Tuchman, and Gary G. Bennett

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Pre-steady-state kinetic analysis of truncated and full-length Saccharomyces cerevisiae DNA polymerase eta, Jessica A. Brown, Likui Zhang, Shanen M. Sherrer, John-Stephen Taylor, Peter M.J. Burgers, and Zucai Suo

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Preventing preterm birth: the past limitations and new potential of animal models, Christine K. Ratajczak, Justin C. Fay, and Louis J. Muglia

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Prevention of healthcare-associated Clostridium difficile infection: What works?, Erik R. Dubberke

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Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function, Susan M. Kennedy, Nicholas O. Davidson, Sebastian Zeissig, Stephanie K. Dougan, Duarte C. Barral, Yvonne Junker, Zhangguo Chen, Arthur Kaser, Madelyn Ho, Hannah Mandel, Adam McIntyre, Gavin F. Painter, Natacha Veerapen, Gurdyal S. Besra, and et al

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Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth, Jevon Plunkett, Scott Doniger, Thomas Morgan, Ritva Haataja, Mikko Hallman, Hilkka Puttonen, Ramkumar Menon, Edward Kuczynski, Errol Norwitz, Victoria Snegovskikh, Aarno Palotie, Leena Peltonen, Vineta Fellman, Emily A. DeFranco, Bimal P. Chaudhari, John Oates, Olivier Boutaud, Tracy L. McGregor, Jude J. McElroy, Kari Teramo, Ingrid Borecki, Justin C. Fay, and Louis J. Muglia

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Principles of research tissue banking and specimen evaluation from the pathologist's perspective, Sarah A. McDonald

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Prominent Degos-like skin lesions in a patient with chronic cutaneous lupus erythematosus, Misha M. Mutizwa, Mark B. Tang, and See Ket Ng

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Promoter and Riboswitch Control of the Mg2+ Transporter MgtA from Salmonella enterica, Michael J. Cromie and Eduardo A. Groisman

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Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination, Yanhong Ji, Alicia J. Little, Joydeep K. Banerjee, Bingtao Hao, Eugene M. Oltz, Michael S. Krangel, and David G. Schatz

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Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery, Xianrong R. Mao and C. Michael Crowder

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Quantification of global myocardial oxygenation in humans: Initial experience, Kyle S. McCommis, Robert O'Connor, Donna Lesniak, Matt Lyons, Pamela K. Woodard, Robert J. Gropler, and Jie Zheng

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Quantification of indirect pathway inhibition by the adenosine A 2a antagonist SYN115 in Parkinson disease, Kevin J. Black, Jonathan M. Koller, Meghan C. Campbell, Debra A. Gusnard, and Stephen I. Bandak

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Quantitation of "autophagic flux" in mature skeletal muscle, Jeong-Sun Ju, Arun S. Varadhachary, Sara E. Miller, and Conrad C. Weihl

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Quantitative biometric phenotype analysis in mouse lenses, Matthew A. Reilly and Usha P. Andley

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Quantitative cardiovascular magnetic resonance for molecular imaging, Patrick M. Winter, Shelton D. Caruthers, Gregory M. Lanza, and Samuel A. Wickline

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RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation, Xiaolin Tian, Ramon U. Jin, Andrew J. Bredemeyer, Edward J. Oates, Katatzyna M. Blazewska, Charles E. McKenna, and Jason C. Mills

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Racial disparities between the sex steroid milieu and the metabolic risk profile, Arlette Perry, Xuewen Wang, Ronald Goldberg, Robert Ross, and Loreto Jackson

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Racial variation in medical outcomes among living kidney donors, Krista L. Lentine, Mark A. Schnitzler, Huiling Xiao, Georges Saab, Paolo R. Salvalaggio, David Axelrod, Connie L. Davis, Kevin C. Abbott, and Daniel C. Brennan