APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading

Authors

Chanung Wang, Washington University School of Medicine in St. Louis
Aishwarya Nambiar, Washington University School of Medicine in St. Louis
Michael R. Strickland, Washington University School of Medicine in St. Louis
Choonghee Lee, Washington University School of Medicine in St. Louis
Samira Parhizkar, Washington University School of Medicine in St. Louis
Alec C. Moore, Washington University School of Medicine in St. Louis
Erik S. Musiek, Washington University School of Medicine in St. Louis
Jason D. Ulrich, Washington University School of Medicine in St. Louis
David M. Holtzman, Washington University School of Medicine in St. Louis

Journal

Journal of Clinical Investigation

Publication Date

7-17-2023

Volume

133

Issue

14

First Page

e169131

Document Type

Open Access Publication

DOI

10.1172/JCI169131

Rights and Permissions

Wang C, Nambiar A, Strickland MR, Lee C, Parhizkar S, Moore AC, Musiek ES, Ulrich JD, Holtzman DM. APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading. J Clin Invest. 2023 Jul 17;133(14):e169131. doi: 10.1172/JCI169131. © 2023, Wang et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License.

Recommended Citation

Wang, Chanung; Nambiar, Aishwarya; Strickland, Michael R.; Lee, Choonghee; Parhizkar, Samira; Moore, Alec C.; Musiek, Erik S.; Ulrich, Jason D.; and Holtzman, David M., "APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading." Journal of Clinical Investigation. 133, 14. e169131 (2023).
https://digitalcommons.wustl.edu/oa_4/2237

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.