Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid

Authors

Francesca M Manzella, University of Colorado
Omar H Cabrera, University of Colorado
Davis Wilkey, University of Colorado
Brier Fine-Raquet, University of Colorado
Jelena Klawitter, University of Colorado
Kathiresan Krishnan, Washington University School of Medicine in St. Louis
Douglas F Covey, Washington University School of Medicine in St. Louis
Vesna Jevtovic-Todorovic, University of Colorado
Slobodan M Todorovic, University of Colorado

Journal

British Journal of Anaesthesia

Publication Date

2-1-2023

Volume

130

Issue

2

First Page

154

Last Page

164

Document Type

Open Access Publication

DOI

10.1016/j.bja.2022.09.025

Rights and Permissions

Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 Feb;130(2):154-164. doi: 10.1016/j.bja.2022.09.025. © 2022 The Authors. Published by Elsevier Ltd on behalf of British Journal of Anaesthesia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Recommended Citation

Manzella, Francesca M; Cabrera, Omar H; Wilkey, Davis; Fine-Raquet, Brier; Klawitter, Jelena; Krishnan, Kathiresan; Covey, Douglas F; Jevtovic-Todorovic, Vesna; and Todorovic, Slobodan M, "Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid." British Journal of Anaesthesia. 130, 2. 154 - 164. (2023).
https://digitalcommons.wustl.edu/oa_4/2468

Additional Links

Supplemental material is available for this article at publisher site.