Combining the tyrosine kinase inhibitor cabozantinib and the mTORC1/2 inhibitor sapanisertib blocks ERK pathway activity and suppresses tumor growth in renal cell carcinoma

Authors

• Yige Wu, Washington University School of Medicine in St. Louis
• Siqi Chen, Washington University School of Medicine in St. Louis
• Xiaolu Yang, Washington University School of Medicine in St. Louis
• Kazuhito Sato, Washington University School of Medicine in St. Louis
• Preet Lal, Washington University School of Medicine in St. Louis
• Andrew T Shinkle, Washington University School of Medicine in St. Louis
• Michael C Wendl, Washington University School of Medicine in St. Louis
• Tina M Primeau, Washington University School of Medicine in St. Louis
• Yanyan Zhao, Washington University School of Medicine in St. Louis
• Alanna Gould, Washington University School of Medicine in St. Louis
• Hua Sun, Washington University School of Medicine in St. Louis
• Jacqueline L Mudd, Washington University School of Medicine in St. Louis
• Jeremy Hoog, Washington University School of Medicine in St. Louis
• R Jay Mashl, Washington University School of Medicine in St. Louis
• Matthew A Wyczalkowski, Washington University School of Medicine in St. Louis
• Chia-Kuei Mo, Washington University School of Medicine in St. Louis
• Ruiyang Liu, Washington University School of Medicine in St. Louis
• John M Herndon, Washington University School of Medicine in St. Louis
• Sherri R Davies, Washington University School of Medicine in St. Louis
• Di Liu, Washington University School of Medicine in St. Louis
• Xi Ding, Washington University School of Medicine in St. Louis
• Ramaswamy Govindan, Washington University School of Medicine in St. Louis
• Shunqiang Li, Washington University School of Medicine in St. Louis
• James Hsieh, Washington University School of Medicine in St. Louis
• Ryan C Fields, Washington University School of Medicine in St. Louis
• Kian-Huat Lim, Washington University School of Medicine in St. Louis
• Cynthia X Ma, Washington University School of Medicine in St. Louis
• Li Ding, Washington University School of Medicine in St. Louis
• Feng Chen, Washington University School of Medicine in St. Louis
• et al.

Journal

Cancer Research

Publication Date

12-15-2023

Volume

83

Issue

24

First Page

4161

Last Page

4178

Document Type

Open Access Publication

DOI

10.1158/0008-5472.CAN-23-0604

Rights and Permissions

Wu Y, Chen S, Yang X, Sato K, Lal P, Wang Y, Shinkle AT, Wendl MC, Primeau TM, Zhao Y, Gould A, Sun H, Mudd JL, Hoog J, Mashl RJ, Wyczalkowski MA, Mo CK, Liu R, Herndon JM, Davies SR, Liu D, Ding X, Evrard YA, Welm BE, Lum D, Koh MY, Welm AL, Chuang JH, Moscow JA, Meric-Bernstam F, Govindan R, Li S, Hsieh J, Fields RC, Lim KH, Ma CX, Zhang H, Ding L, Chen F. Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma. Cancer Res. 2023 Dec 15;83(24):4161-4178. doi: 10.1158/0008-5472.CAN-23-0604. ©2023 The Authors; Published by the American Association for Cancer Research This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

Recommended Citation

Wu, Yige; Chen, Siqi; Yang, Xiaolu; Sato, Kazuhito; Lal, Preet; Shinkle, Andrew T; Wendl, Michael C; Primeau, Tina M; Zhao, Yanyan; Gould, Alanna; Sun, Hua; Mudd, Jacqueline L; Hoog, Jeremy; Mashl, R Jay; Wyczalkowski, Matthew A; Mo, Chia-Kuei; Liu, Ruiyang; Herndon, John M; Davies, Sherri R; Liu, Di; Ding, Xi; Govindan, Ramaswamy; Li, Shunqiang; Hsieh, James; Fields, Ryan C; Lim, Kian-Huat; Ma, Cynthia X; Ding, Li; Chen, Feng; and et al., "Combining the tyrosine kinase inhibitor cabozantinib and the mTORC1/2 inhibitor sapanisertib blocks ERK pathway activity and suppresses tumor growth in renal cell carcinoma." Cancer Research. 83, 24. 4161 - 4178. (2023).
https://digitalcommons.wustl.edu/oa_4/3122

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.