HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

Authors

Sheng Chen, Washington University in St. Louis
Anuradhika Puri, Washington University in St. Louis
Braxton Bell, Washington University in St. Louis
Joseph Fritsche, Washington University in St. Louis
Hector H Palacios, Washington University School of Medicine in St. Louis
Maurie Balch, Washington University in St. Louis
Macy L Sprunger, Washington University in St. Louis
Matthew K Howard, Washington University in St. Louis
Jeremy J Ryan, Washington University in St. Louis
Jessica N Haines, Washington University School of Medicine in St. Louis
Gary J Patti, Washington University School of Medicine in St. Louis
Albert A Davis, Washington University School of Medicine in St. Louis
Meredith E Jackrel, Washington University in St. Louis

Journal

Nature Communications

Publication Date

3-18-2024

Volume

15

Issue

1

First Page

2436

Document Type

Open Access Publication

DOI

10.1038/s41467-024-46538-8

Rights and Permissions

Chen, S., Puri, A., Bell, B. et al. HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species. Nat Commun 15, 2436 (2024). https://doi.org/10.1038/s41467-024-46538-8 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Chen, Sheng; Puri, Anuradhika; Bell, Braxton; Fritsche, Joseph; Palacios, Hector H; Balch, Maurie; Sprunger, Macy L; Howard, Matthew K; Ryan, Jeremy J; Haines, Jessica N; Patti, Gary J; Davis, Albert A; and Jackrel, Meredith E, "HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species." Nature Communications. 15, 1. 2436 (2024).
https://digitalcommons.wustl.edu/oa_4/3558

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.