Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer

Authors

• Daniel Cui Zhou, Washington University School of Medicine in St. Louis
• Reyka G Jayasinghe, Washington University School of Medicine in St. Louis
• Siqi Chen, Washington University School of Medicine in St. Louis
• John M Herndon, Washington University School of Medicine in St. Louis
• Michael D Iglesia, Washington University School of Medicine in St. Louis
• Pooja Navale, Washington University School of Medicine in St. Louis
• Michael C Wendl, Washington University School of Medicine in St. Louis
• Wagma Caravan, Washington University School of Medicine in St. Louis
• Kazuhito Sato, Washington University School of Medicine in St. Louis
• Erik Storrs, Washington University School of Medicine in St. Louis
• Chia-Kuei Mo, Washington University School of Medicine in St. Louis
• Jingxian Liu, Washington University School of Medicine in St. Louis
• Austin N Southard-Smith, Washington University School of Medicine in St. Louis
• Yige Wu, Washington University School of Medicine in St. Louis
• Nataly Naser Al Deen, Washington University School of Medicine in St. Louis
• John M Baer, Washington University School of Medicine in St. Louis
• Robert S Fulton, Washington University School of Medicine in St. Louis
• Matthew A Wyczalkowski, Washington University School of Medicine in St. Louis
• Ruiyang Liu, Washington University School of Medicine in St. Louis
• Catrina C Fronick, Washington University School of Medicine in St. Louis
• Lucinda A Fulton, Washington University School of Medicine in St. Louis
• Andrew Shinkle, Washington University School of Medicine in St. Louis
• Lisa Thammavong, Washington University School of Medicine in St. Louis
• Houxiang Zhu, Washington University School of Medicine in St. Louis
• Hua Sun, Washington University School of Medicine in St. Louis
• Liang-Bo Wang, Washington University School of Medicine in St. Louis
• Yize Li, Washington University School of Medicine in St. Louis
• Chong Zuo, Washington University School of Medicine in St. Louis
• Joshua F McMichael, Washington University School of Medicine in St. Louis
• Sherri R Davies, Washington University School of Medicine in St. Louis
• Elizabeth L Appelbaum, Washington University School of Medicine in St. Louis
• Keenan J Robbins, Washington University School of Medicine in St. Louis
• Sara E Chasnoff, Washington University School of Medicine in St. Louis
• Xiaolu Yang, Washington University School of Medicine in St. Louis
• Ashley N Reeb, Washington University School of Medicine in St. Louis
• Clara Oh, Washington University School of Medicine in St. Louis
• Mamatha Serasanambati, Washington University School of Medicine in St. Louis
• Preet Lal, Washington University School of Medicine in St. Louis
• Rajees Varghese, Washington University School of Medicine in St. Louis
• Jay R Mashl, Washington University School of Medicine in St. Louis
• Jennifer Ponce, Washington University School of Medicine in St. Louis
• Nadezhda V Terekhanova, Washington University School of Medicine in St. Louis
• Lijun Yao, Washington University School of Medicine in St. Louis
• Rita Jui-Hsien Lu, Washington University School of Medicine in St. Louis
• Julie K Schwarz, Washington University School of Medicine in St. Louis
• Sidharth V Puram, Washington University School of Medicine in St. Louis
• Albert H Kim, Washington University School of Medicine in St. Louis
• Sheng-Kwei Song, Washington University School of Medicine in St. Louis
• Kooresh I Shoghi, Washington University School of Medicine in St. Louis
• William G Hawkins, Washington University School of Medicine in St. Louis
• Samuel Achilefu, Washington University School of Medicine in St. Louis
• Milan G Chheda, Washington University School of Medicine in St. Louis
• Stephen T Oh, Washington University School of Medicine in St. Louis
• William E Gillanders, Washington University School of Medicine in St. Louis
• Feng Chen, Washington University School of Medicine in St. Louis
• David G DeNardo, Washington University School of Medicine in St. Louis
• Ryan C Fields, Washington University School of Medicine in St. Louis
• Li Ding, Washington University School of Medicine in St. Louis
• et al

Journal

Nature Genetics

Publication Date

9-1-2022

Volume

54

Issue

9

First Page

1390

Last Page

1405

Document Type

Open Access Publication

DOI

10.1038/s41588-022-01157-1

Rights and Permissions

Cui Zhou, D., Jayasinghe, R.G., Chen, S. et al. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet 54, 1390–1405 (2022). https://doi.org/10.1038/s41588-022-01157-1 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Cui Zhou, Daniel; Jayasinghe, Reyka G; Chen, Siqi; Herndon, John M; Iglesia, Michael D; Navale, Pooja; Wendl, Michael C; Caravan, Wagma; Sato, Kazuhito; Storrs, Erik; Mo, Chia-Kuei; Liu, Jingxian; Southard-Smith, Austin N; Wu, Yige; Naser Al Deen, Nataly; Baer, John M; Fulton, Robert S; Wyczalkowski, Matthew A; Liu, Ruiyang; Fronick, Catrina C; Fulton, Lucinda A; Shinkle, Andrew; Thammavong, Lisa; Zhu, Houxiang; Sun, Hua; Wang, Liang-Bo; Li, Yize; Zuo, Chong; McMichael, Joshua F; Davies, Sherri R; Appelbaum, Elizabeth L; Robbins, Keenan J; Chasnoff, Sara E; Yang, Xiaolu; Reeb, Ashley N; Oh, Clara; Serasanambati, Mamatha; Lal, Preet; Varghese, Rajees; Mashl, Jay R; Ponce, Jennifer; Terekhanova, Nadezhda V; Yao, Lijun; Lu, Rita Jui-Hsien; Schwarz, Julie K; Puram, Sidharth V; Kim, Albert H; Song, Sheng-Kwei; Shoghi, Kooresh I; Hawkins, William G; Achilefu, Samuel; Chheda, Milan G; Oh, Stephen T; Gillanders, William E; Chen, Feng; DeNardo, David G; Fields, Ryan C; Ding, Li; and et al, "Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer." Nature Genetics. 54, 9. 1390 - 1405. (2022).
https://digitalcommons.wustl.edu/oa_4/362