Journal
Nature Genetics
Publication Date
9-1-2022
Volume
54
Issue
9
First Page
1390
Last Page
1405
Document Type
Open Access Publication
DOI
10.1038/s41588-022-01157-1
Rights and Permissions
Cui Zhou, D., Jayasinghe, R.G., Chen, S. et al. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet 54, 1390–1405 (2022). https://doi.org/10.1038/s41588-022-01157-1 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Recommended Citation
Cui Zhou, Daniel; Jayasinghe, Reyka G; Chen, Siqi; Herndon, John M; Iglesia, Michael D; Navale, Pooja; Wendl, Michael C; Caravan, Wagma; Sato, Kazuhito; Storrs, Erik; Mo, Chia-Kuei; Liu, Jingxian; Southard-Smith, Austin N; Wu, Yige; Naser Al Deen, Nataly; Baer, John M; Fulton, Robert S; Wyczalkowski, Matthew A; Liu, Ruiyang; Fronick, Catrina C; Fulton, Lucinda A; Shinkle, Andrew; Thammavong, Lisa; Zhu, Houxiang; Sun, Hua; Wang, Liang-Bo; Li, Yize; Zuo, Chong; McMichael, Joshua F; Davies, Sherri R; Appelbaum, Elizabeth L; Robbins, Keenan J; Chasnoff, Sara E; Yang, Xiaolu; Reeb, Ashley N; Oh, Clara; Serasanambati, Mamatha; Lal, Preet; Varghese, Rajees; Mashl, Jay R; Ponce, Jennifer; Terekhanova, Nadezhda V; Yao, Lijun; Lu, Rita Jui-Hsien; Schwarz, Julie K; Puram, Sidharth V; Kim, Albert H; Song, Sheng-Kwei; Shoghi, Kooresh I; Hawkins, William G; Achilefu, Samuel; Chheda, Milan G; Oh, Stephen T; Gillanders, William E; Chen, Feng; DeNardo, David G; Fields, Ryan C; Ding, Li; and et al, "Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer." Nature Genetics. 54, 9. 1390 - 1405. (2022).
https://digitalcommons.wustl.edu/oa_4/362
Supplementary Note and Fig. 1
41588_2022_1157_MOESM2_ESM.pdf (3215 kB)
Reporting Summary
41588_2022_1157_MOESM3_ESM.xlsx (48 kB)
Supplementary Tables 1–5
41588_2022_1157_MOESM4_ESM.xlsx (31703 kB)
Bulk omics data including somatic and germline variants and proteogenomics data
41588_2022_1157_MOESM5_ESM.txt (112915 kB)
CNVkit raw copy number calls across the sample set
41588_2022_1157_MOESM6_ESM.xlsx (15 kB)
Total cell count of transitional cell populations and mutation mapping across samples
41588_2022_1157_MOESM7_ESM.xlsx (979 kB)
Differentially expressed genes (DEGs) identified by annotating spatial transcriptomics spots using the Loupe Browser and Seurat. FindAllMarkers function from Seurat was used to identify DEGs
41588_2022_1157_MOESM8_ESM.txt (7 kB)
Tumor purity estimates predicted by ABSOLUTE across sample cohort
