Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells

Authors

Natasha Ramakrishnan, Washington University School of Medicine in St. Louis
Tyler M Weaver, University of Kansas
Lindsey N Aubuchon, Washington University School of Medicine in St. Louis
Ayda Woldegerima, Washington University School of Medicine in St. Louis
Taylor Just, Washington University School of Medicine in St. Louis
Kevin Song, Washington University School of Medicine in St. Louis
Alessandro Vindigni, Washington University School of Medicine in St. Louis
Bret D Freudenthal, University of Kansas
Priyanka Verma, Washington University School of Medicine in St. Louis

Journal

Nature Communications

Publication Date

7-27-2024

Volume

15

Issue

1

First Page

6343

Document Type

Open Access Publication

DOI

10.1038/s41467-024-50673-7

Rights and Permissions

Ramakrishnan, N., Weaver, T.M., Aubuchon, L.N. et al. Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells. Nat Commun 15, 6343 (2024). https://doi.org/10.1038/s41467-024-50673-7 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Ramakrishnan, Natasha; Weaver, Tyler M; Aubuchon, Lindsey N; Woldegerima, Ayda; Just, Taylor; Song, Kevin; Vindigni, Alessandro; Freudenthal, Bret D; and Verma, Priyanka, "Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells." Nature Communications. 15, 1. 6343 (2024).
https://digitalcommons.wustl.edu/oa_4/4045

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.