Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis

Authors

Ruhang Tang, Washington University School of Medicine in St. Louis
Natalia S Harasymowicz, Washington University School of Medicine in St. Louis
Chia-Lung Wu, Washington University in St. Louis
Yun-Rak Choi, Washington University School of Medicine in St. Louis
Kristin Lenz, Washington University School of Medicine in St. Louis
Sara J Oswald, Washington University School of Medicine in St. Louis
Farshid Guilak, Washington University School of Medicine in St. Louis

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Date

10-22-2024

Volume

121

Issue

43

First Page

e2402954121

Document Type

Open Access Publication

DOI

10.1073/pnas.2402954121

Rights and Permissions

Tang R, Harasymowicz NS, Wu CL, Choi YR, Lenz K, Oswald SJ, Guilak F. Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis. Proc Natl Acad Sci U S A. 2024 Oct 22;121(43):e2402954121. doi: 10.1073/pnas.2402954121 Copyright © 2024 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Recommended Citation

Tang, Ruhang; Harasymowicz, Natalia S; Wu, Chia-Lung; Choi, Yun-Rak; Lenz, Kristin; Oswald, Sara J; and Guilak, Farshid, "Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis." Proceedings of the National Academy of Sciences of the United States of America. 121, 43. e2402954121 (2024).
https://digitalcommons.wustl.edu/oa_4/4335

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.