Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: Synthesis, biological evaluations and modelling insights

Authors

Waleed A Badawi, Damanhour University
Mahmoud Rashed, Al-Azhar University
Alessio Nocentini, University of Florence
Alessandro Bonardi, University of Florence
Mohammad M Abd-Alhaseeb, Damanhour University
Sara T Al-Rashood, King Saud University
Giri Babu Veerakanellore, Washington University School of Medicine in St. Louis
Taghreed A Majrashi, King Khalid University
Eslam B Elkaeed, AlMaarefa University
Bahaa Elgendy, Washington University School of Medicine in St. Louis
Paola Gratteri, University of Florence
Claudiu T Supuran, University of Florence
Wagdy M Eldehna, Kafrelsheikh University
Mohamed Elagawany, Damanhour University

Journal

Journal of Enzyme Inhibition and Medicinal Chemistry

Publication Date

12-1-2023

Volume

38

Issue

1

First Page

2201407

Document Type

Open Access Publication

DOI

10.1080/14756366.2023.2201407

Rights and Permissions

Badawi WA, Rashed M, Nocentini A, Bonardi A, Abd-Alhaseeb MM, Al-Rashood ST, Veerakanellore GB, Majrashi TA, Elkaeed EB, Elgendy B, Gratteri P, Supuran CT, Eldehna WM, Elagawany M. Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407. doi: 10.1080/14756366.2023.2201407. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

Recommended Citation

Badawi, Waleed A; Rashed, Mahmoud; Nocentini, Alessio; Bonardi, Alessandro; Abd-Alhaseeb, Mohammad M; Al-Rashood, Sara T; Veerakanellore, Giri Babu; Majrashi, Taghreed A; Elkaeed, Eslam B; Elgendy, Bahaa; Gratteri, Paola; Supuran, Claudiu T; Eldehna, Wagdy M; and Elagawany, Mohamed, "Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: Synthesis, biological evaluations and modelling insights." Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1. 2201407 (2023).
https://digitalcommons.wustl.edu/oa_4/4558

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.