Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cantú syndrome

Authors

Lotte Kleinendorst, University of Amsterdam
Sarah E Siegelaar, University of Amsterdam
Helen I Roessler, Amsterdam University Medical Center
Lema Meiwand, University of Amsterdam
Malou van den Boogaard, University of Amsterdam
Rianne H A C M de Bruin-Bon, University of Amsterdam
Kirsten F van Duinen, Ziekenhuis Nij Smellinghe
R Nils Planken, University of Amsterdam
Elisabeth H Jaspars, University of Amsterdam
Patrick M J H Kemperman, University of Amsterdam
Berto J Bouma, University of Amsterdam
Colin G Nichols, Washington University School of Medicine in St. Louis
Marcel W Bekkenk, University of Amsterdam
Gijs W van Haaften, University Medical Center Utrecht
Mieke M van Haelst, University of Amsterdam

Journal

Scientific Reports

Publication Date

5-21-2025

Volume

15

Issue

1

First Page

17704

Document Type

Open Access Publication

DOI

10.1038/s41598-025-00547-9

Rights and Permissions

Kleinendorst, L., Siegelaar, S.E., Roessler, H.I. et al. Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cantú syndrome. Sci Rep 15, 17704 (2025). https://doi.org/10.1038/s41598-025-00547-9 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Kleinendorst, Lotte; Siegelaar, Sarah E; Roessler, Helen I; Meiwand, Lema; van den Boogaard, Malou; de Bruin-Bon, Rianne H A C M; van Duinen, Kirsten F; Planken, R Nils; Jaspars, Elisabeth H; Kemperman, Patrick M J H; Bouma, Berto J; Nichols, Colin G; Bekkenk, Marcel W; van Haaften, Gijs W; and van Haelst, Mieke M, "Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cantú syndrome." Scientific Reports. 15, 1. 17704 (2025).
https://digitalcommons.wustl.edu/oa_4/5243

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.