Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels

Authors

Kate Harris, University of California, San Francisco
Seok Joon Won, University of California, San Francisco
Gokhan Uruk, University of California, San Francisco
Nguyen Mai, University of California, San Francisco
Devran Ogut, San Francisco Veterans Affairs Health Care System
Yonghui Zhao, Washington University School of Medicine in St. Louis
Litao Xie, Washington University School of Medicine in St. Louis
Paul Baxter, University of California, San Francisco
Katharina Everaerts, University of California, San Francisco
Rajan Sah, Washington University School of Medicine in St. Louis
Raymond A Swanson, University of California, San Francisco

Journal

Science Advances

Publication Date

8-29-2025

Volume

11

Issue

35

First Page

eadw0424

Document Type

Open Access Publication

DOI

10.1126/sciadv.adw0424

Rights and Permissions

Harris K, Won SJ, Uruk G, Mai N, Ogut D, Zhao Y, Xie L, Baxter P, Everaerts K, Sah R, Swanson RA. Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels. Sci Adv. 2025 Aug 29;11(35):eadw0424. doi: 10.1126/sciadv.adw0424 Copyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

Recommended Citation

Harris, Kate; Won, Seok Joon; Uruk, Gokhan; Mai, Nguyen; Ogut, Devran; Zhao, Yonghui; Xie, Litao; Baxter, Paul; Everaerts, Katharina; Sah, Rajan; and Swanson, Raymond A, "Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels." Science Advances. 11, 35. eadw0424 (2025).
https://digitalcommons.wustl.edu/oa_4/5275

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.