Novel neuroactive steroid analogs and voltage-dependent blockers of CaV3.2 currents, B372 and YX23, are effective anti-nociceptives with diminished sedative properties in intact female mice

Authors

Benjamin Volvovitz, University of Colorado
Rakib Miah, University of Colorado
Kibeom Park, Keimyung University
Jae Hun Kim, Keimyung University
Raul Vargas, University of Colorado
Yuanjiang Xu, Washington University School of Medicine in St. Louis
Mingxing Qian, Washington University School of Medicine in St. Louis
Douglas F Covey, Washington University School of Medicine in St. Louis
Slobodan M Todorovic, University of Colorado
Vesna Jevtovic-Todorovic, University of Colorado

Journal

Biomolecules

Publication Date

8-16-2025

Volume

15

Issue

8

First Page

1175

Document Type

Open Access Publication

DOI

10.3390/biom15081175

Rights and Permissions

Volvovitz B, Miah R, Park K, Kim JH, Vargas R, Xu Y, Qian M, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Novel Neuroactive Steroid Analogs and Voltage-Dependent Blockers of CaV3.2 Currents, B372 and YX23, Are Effective Anti-Nociceptives with Diminished Sedative Properties in Intact Female Mice. Biomolecules. 2025 Aug 16;15(8):1175. doi: 10.3390/biom15081175 Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).

Recommended Citation

Volvovitz, Benjamin; Miah, Rakib; Park, Kibeom; Kim, Jae Hun; Vargas, Raul; Xu, Yuanjiang; Qian, Mingxing; Covey, Douglas F; Todorovic, Slobodan M; and Jevtovic-Todorovic, Vesna, "Novel neuroactive steroid analogs and voltage-dependent blockers of CaV3.2 currents, B372 and YX23, are effective anti-nociceptives with diminished sedative properties in intact female mice." Biomolecules. 15, 8. 1175 (2025).
https://digitalcommons.wustl.edu/oa_4/5290