Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism

Authors

Tae Jun Lee, Washington University School of Medicine in St. Louis
Andrea Santeford, Washington University School of Medicine in St. Louis
Kristen M Pitts, Washington University School of Medicine in St. Louis
Carla Valenzuela Ripoll, Washington University School of Medicine in St. Louis
Ryo Terao, Washington University School of Medicine in St. Louis
Zhen Guo, Washington University School of Medicine in St. Louis
Mualla Ozcan, Washington University School of Medicine in St. Louis
Dagmar Kratky, Medical University of Graz
Christina Christoffersen, University of Copenhagen
Ali Javaheri, Washington University School of Medicine in St. Louis
Rajendra S Apte, Washington University School of Medicine in St. Louis

Journal

Nature Communications

Publication Date

6-24-2025

Volume

16

Issue

1

First Page

5331

Document Type

Open Access Publication

DOI

10.1038/s41467-025-60830-1

Rights and Permissions

Lee, T.J., Santeford, A., Pitts, K.M. et al. Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism. Nat Commun 16, 5331 (2025). https://doi.org/10.1038/s41467-025-60830-1 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Lee, Tae Jun; Santeford, Andrea; Pitts, Kristen M; Ripoll, Carla Valenzuela; Terao, Ryo; Guo, Zhen; Ozcan, Mualla; Kratky, Dagmar; Christoffersen, Christina; Javaheri, Ali; and Apte, Rajendra S, "Apolipoprotein M attenuates age-related macular degeneration phenotypes via sphingosine-1-phosphate signaling and lysosomal lipid catabolism." Nature Communications. 16, 1. 5331 (2025).
https://digitalcommons.wustl.edu/oa_4/5608

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.