Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection

Authors

Maria D H Alcorn, University of Pittsburgh
Chengqun Sun, University of Pittsburgh
Theron C Gilliland Jr, University of Pittsburgh
Tetyana Lukash, University of Pittsburgh
Christine M Crasto, University of Pittsburgh
Saravanan Raju, Washington University School of Medicine in St. Louis
Michael S Diamond, Washington University School of Medicine in St. Louis
Scott C Weaver, University of Texas Medical Branch
William B Klimstra, University of Pittsburgh

Journal

Nature Communications

Publication Date

8-5-2025

Volume

16

Issue

1

First Page

7227

Document Type

Open Access Publication

DOI

10.1038/s41467-025-62513-3

Rights and Permissions

Alcorn, M.D.H., Sun, C., Gilliland, T.C. et al. Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection. Nat Commun 16, 7227 (2025). https://doi.org/10.1038/s41467-025-62513-3 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Alcorn, Maria D H; Sun, Chengqun; Gilliland, Theron C Jr; Lukash, Tetyana; Crasto, Christine M; Raju, Saravanan; Diamond, Michael S; Weaver, Scott C; and Klimstra, William B, "Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection." Nature Communications. 16, 1. 7227 (2025).
https://digitalcommons.wustl.edu/oa_4/5622

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

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