Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3 H)-one via C-H activation: Development of synthetic TLX agonists

Authors

Lingaiah Maram, Washington University School of Medicine in St. Louis
Puhan Zhao, Washington University School of Medicine in St. Louis
Thomas Koelblen, University of Florida
Lamees Hegazy, Washington University School of Medicine in St. Louis
Thomas P Burris, University of Florida
Bahaa Elgendy, Washington University School of Medicine in St. Louis

Journal

Organic & Biomolecular Chemistry

Publication Date

8-6-2025

Volume

23

Issue

31

First Page

7298

Last Page

7313

Document Type

Open Access Publication

DOI

10.1039/d5ob00672d

Rights and Permissions

Maram L, Zhao P, Koelblen T, Hegazy L, Burris TP, Elgendy B. Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C-H activation: development of synthetic TLX agonists. Org Biomol Chem. 2025 Aug 6;23(31):7298-7313. doi: 10.1039/d5ob00672d.This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Recommended Citation

Maram, Lingaiah; Zhao, Puhan; Koelblen, Thomas; Hegazy, Lamees; Burris, Thomas P; and Elgendy, Bahaa, "Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3 H)-one via C-H activation: Development of synthetic TLX agonists." Organic & Biomolecular Chemistry. 23, 31. 7298 - 7313. (2025).
https://digitalcommons.wustl.edu/oa_4/5647

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.