Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan

Authors

Siqi Chen, Washington University School of Medicine in St. Louis
Ruiyang Liu, Washington University School of Medicine in St. Louis
Chia-Kuei Mo, Washington University School of Medicine in St. Louis
Michael C Wendl, Washington University School of Medicine in St. Louis
Andrew Houston, Washington University School of Medicine in St. Louis
Preet Lal, Washington University School of Medicine in St. Louis
Yanyan Zhao, Washington University School of Medicine in St. Louis
Wagma Caravan, Washington University School of Medicine in St. Louis
Andrew T Shinkle, Washington University School of Medicine in St. Louis
Atieh Abedin-Do, Washington University School of Medicine in St. Louis
Nataly Naser Al Deen, Washington University School of Medicine in St. Louis
Kazuhito Sato, Washington University School of Medicine in St. Louis
Xiang Li, Washington University School of Medicine in St. Louis
André Luiz N Targino da Costa, Washington University School of Medicine in St. Louis
Yize Li, Washington University School of Medicine in St. Louis
Alla Karpova, Washington University School of Medicine in St. Louis
John M Herndon, Washington University School of Medicine in St. Louis
Maxim N Artyomov, Washington University School of Medicine in St. Louis
Joshua B Rubin, Washington University School of Medicine in St. Louis
Sanjay Jain, Washington University School of Medicine in St. Louis
Sheila A Stewart, Washington University School of Medicine in St. Louis
Li Ding, Washington University School of Medicine in St. Louis
Feng Chen, Washington University School of Medicine in St. Louis
et al.

Journal

Nature Genetics

Publication Date

5-1-2025

Volume

57

Issue

5

First Page

1213

Last Page

1227

Document Type

Open Access Publication

DOI

10.1038/s41588-025-02161-x

Rights and Permissions

Chen, S., Liu, R., Mo, CK. et al. Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan. Nat Genet 57, 1213–1227 (2025). https://doi.org/10.1038/s41588-025-02161-x This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Chen, Siqi; Liu, Ruiyang; Mo, Chia-Kuei; Wendl, Michael C; Houston, Andrew; Lal, Preet; Zhao, Yanyan; Caravan, Wagma; Shinkle, Andrew T; Abedin-Do, Atieh; Naser Al Deen, Nataly; Sato, Kazuhito; Li, Xiang; Targino da Costa, André Luiz N; Li, Yize; Karpova, Alla; Herndon, John M; Artyomov, Maxim N; Rubin, Joshua B; Jain, Sanjay; Stewart, Sheila A; Ding, Li; Chen, Feng; and et al., "Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan." Nature Genetics. 57, 5. 1213 - 1227. (2025).
https://digitalcommons.wustl.edu/oa_4/6106

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.