Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria

Authors

Milena Tavares Gomes, Federal University of Juiz de Fora, Brazil
Robert A Campbell, Washington University School of Medicine in St. Louis
et al.

Journal

Blood Advances

Publication Date

2-10-2026

Volume

10

Issue

3

First Page

575

Last Page

592

Document Type

Open Access Publication

DOI

10.1182/bloodadvances.2024015623

Rights and Permissions

Gomes MT, Medeiros-de-Moraes IM, Vieira-de-Abreu A, de Azevedo-Quintanilha IG, Fontes TM, de Brito Carneiro A, Azambuja P, Tolley ND, Rowley JW, Carpinter BA, Ferreira MU, Gonçalves RM, Rocha VN, Rosa Nascimento AL, Carvalho WA, Scopel KKG, Campbell RA, Bozza PT, Weyrich AS, Zimmerman GA, Lacerda MVG, Castro-Faria-Neto HC, Hottz ED. Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria. Blood Adv. 2026 Feb 10;10(3):575-592. doi: 10.1182/bloodadvances.2024015623. © 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

Recommended Citation

Gomes, Milena Tavares; Campbell, Robert A; and et al., "Heme and hemozoin induce platelet cell death through UPR-induced apoptosis and ferroptosis in vivax malaria." Blood Advances. 10, 3. 575 - 592. (2026).
https://digitalcommons.wustl.edu/oa_4/6375

Additional Links

Supplemental material is available for this article at publisher site.