The effect of increased weight loading on body weight is partly dependent on Piezo1 in osteoblast-lineage cells and TrkA signaling

Authors

• Daniel Hägg, University of Gothenburg
• Lei Li, University of Gothenburg
• Alec T Beeve, Washington University School of Medicine in St. Louis
• Erica L Scheller, Washington University School of Medicine in St. Louis
• Jakob Bellman, University of Gothenburg
• Fredrik Anesten, University of Gothenburg
• Jovana Zlatkovic, University of Gothenburg
• Adrià Dalmau Gasull, University of Gothenburg
• Ferran Font-Gironès, University of Gothenburg
• Sofia Movérare-Skrtic, University of Gothenburg
• John-Olov Jansson, University of Gothenburg
• Claes Ohlsson, University of Gothenburg

Journal

Scientific Reports

Publication Date

2-18-2026

Volume

16

Issue

1

First Page

7162

Document Type

Open Access Publication

DOI

10.1038/s41598-026-40431-8

Rights and Permissions

Hägg, D., Li, L., Beeve, A.T. et al. The effect of increased weight loading on body weight is partly dependent on Piezo1 in osteoblast-lineage cells and TrkA signaling. Sci Rep 16, 7162 (2026). https://doi.org/10.1038/s41598-026-40431-8 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Hägg, Daniel; Li, Lei; Beeve, Alec T; Scheller, Erica L; Bellman, Jakob; Anesten, Fredrik; Zlatkovic, Jovana; Dalmau Gasull, Adrià; Font-Gironès, Ferran; Movérare-Skrtic, Sofia; Jansson, John-Olov; and Ohlsson, Claes, "The effect of increased weight loading on body weight is partly dependent on Piezo1 in osteoblast-lineage cells and TrkA signaling." Scientific Reports. 16, 1. 7162 (2026).
https://digitalcommons.wustl.edu/oa_4/6494

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.