Synthetic lethality of decitabine plus ATR inhibition for TP53-mutated AML

Authors

• Jeremy T Baeten, Washington University School of Medicine in St. Louis
• Sumedha Agashe, Washington University School of Medicine in St. Louis
• Imene Tabet, Washington University School of Medicine in St. Louis
• Jack T Wooldridge, Washington University School of Medicine in St. Louis
• Amber Carter, Washington University School of Medicine in St. Louis
• Jamie N Butler, Washington University School of Medicine in St. Louis
• Christopher A Miller, Washington University School of Medicine in St. Louis
• Nicole Helton, Washington University School of Medicine in St. Louis
• Annabel Quinet, Université Paris-Saclay
• Kimberly B Johansson, Washington University School of Medicine in St. Louis
• Yichan Yang, Washington University School of Medicine in St. Louis
• Geoffrey L Uy, Washington University School of Medicine in St. Louis
• Alessandro Vindigni, Washington University School of Medicine in St. Louis
• Daniel C Link, Washington University School of Medicine in St. Louis

Journal

Blood Advances

Publication Date

4-14-2026

Volume

10

Issue

7

First Page

2506

Last Page

2520

Document Type

Open Access Publication

DOI

10.1182/bloodadvances.2025018369

Rights and Permissions

Baeten JT, Agashe S, Tabet I, Wooldridge JT, Carter A, Butler JN, Miller CA, Helton N, Quinet A, Johansson KB, Yang Y, Uy GL, Vindigni A, Link DC. Synthetic lethality of decitabine plus ATR inhibition for TP53-mutated AML. Blood Adv. 2026 Apr 14;10(7):2506-2520. doi: 10.1182/bloodadvances.2025018369. © 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

Recommended Citation

Baeten, Jeremy T; Agashe, Sumedha; Tabet, Imene; Wooldridge, Jack T; Carter, Amber; Butler, Jamie N; Miller, Christopher A; Helton, Nicole; Quinet, Annabel; Johansson, Kimberly B; Yang, Yichan; Uy, Geoffrey L; Vindigni, Alessandro; and Link, Daniel C, "Synthetic lethality of decitabine plus ATR inhibition for TP53-mutated AML." Blood Advances. 10, 7. 2506 - 2520. (2026).
https://digitalcommons.wustl.edu/oa_4/6515

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.