Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema

Authors

• Sven Kerst, Amsterdam University Medical Center
• Leoni Hoogterp, Amsterdam University Medical Center
• Marjolein Breur, Amsterdam University Medical Center
• Gemma M van Rooijen-van Leeuwen, Amsterdam University Medical Center
• Marianna Bugiani, Amsterdam University Medical Center
• Rajan Sah, Washington University School of Medicine in St. Louis
• Huibert D Mansvelder, Amsterdam University Medical Center
• Marjo S van der Knaap, Amsterdam University Medical Center
• Rogier Min, Amsterdam University Medical Center

Journal

Neurobiology of Disease

Publication Date

3-1-2026

Volume

220

First Page

107313

Document Type

Open Access Publication

DOI

10.1016/j.nbd.2026.107313

Rights and Permissions

Kerst S, Hoogterp L, Breur M, van Rooijen-van Leeuwen GM, Bugiani M, Sah R, Mansvelder HD, van der Knaap MS, Min R. Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema. Neurobiol Dis. 2026 Mar;220:107313. doi: 10.1016/j.nbd.2026.107313. © 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Recommended Citation

Kerst, Sven; Hoogterp, Leoni; Breur, Marjolein; van Rooijen-van Leeuwen, Gemma M; Bugiani, Marianna; Sah, Rajan; Mansvelder, Huibert D; van der Knaap, Marjo S; and Min, Rogier, "Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema." Neurobiology of Disease. 220, 107313 (2026).
https://digitalcommons.wustl.edu/oa_4/6537

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.