LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD

Authors

• Rawdat Hussain, University of Michigan - Ann Arbor
• Chinmay Raut, University of Michigan - Ann Arbor
• Ponnandy Prabhu, University of Michigan - Ann Arbor
• Akram Irshaid, University of Michigan - Ann Arbor
• Yash Hegde, University of Wisconsin - Madison
• Yue Chen, University of Michigan - Ann Arbor
• Asmita Pant, Genentech
• Antonino Oliveri, University of Michigan - Ann Arbor
• Xiaochao Wei, Washington University School of Medicine in St. Louis
• Lishi Yin, University of Michigan - Ann Arbor
• Tiffany L Russell, University of Michigan - Ann Arbor
• Brian Halligan, University of Michigan - Ann Arbor
• Clay F Semenkovich, Washington University School of Medicine in St. Louis
• Elizabeth K Speliotes, University of Michigan - Ann Arbor

Journal

Journal of Lipid Research

Publication Date

4-1-2026

Volume

67

Issue

4

First Page

101013

Document Type

Open Access Publication

DOI

10.1016/j.jlr.2026.101013

Rights and Permissions

Hussain R, Raut C, Prabhu P, Irshaid A, Hegde Y, Chen Y, Pant A, Oliveri A, Wei X, Yin L, Russell TL, Halligan B, Semenkovich CF, Speliotes EK. LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD. J Lipid Res. 2026 Apr;67(4):101013. doi: 10.1016/j.jlr.2026.101013. © 2026 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Recommended Citation

Hussain, Rawdat; Raut, Chinmay; Prabhu, Ponnandy; Irshaid, Akram; Hegde, Yash; Chen, Yue; Pant, Asmita; Oliveri, Antonino; Wei, Xiaochao; Yin, Lishi; Russell, Tiffany L; Halligan, Brian; Semenkovich, Clay F; and Speliotes, Elizabeth K, "LYPLAL1 rare loss-of-function variants in humans and deletion in human hepatoma cells protect against MASLD." Journal of Lipid Research. 67, 4. 101013 (2026).
https://digitalcommons.wustl.edu/oa_4/6586

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.