Biophysical simulation enables segmentation and nervous system atlas mapping for image first spatial omics

Authors

• Lina Mohammed Ali, Washington University School of Medicine in St. Louis
• Aldrin Kay Yuen Yim, Washington University School of Medicine in St. Louis
• Emanuel Gerbi, Washington University School of Medicine in St. Louis
• Thien Nguyen, Washington University School of Medicine in St. Louis
• Nicholas Tu, Washington University School of Medicine in St. Louis
• Faith Ikede, Washington University School of Medicine in St. Louis
• Remi Sampaleanu, Washington University School of Medicine in St. Louis
• Diana Grigore, Washington University School of Medicine in St. Louis
• Jason Waligorski, Washington University School of Medicine in St. Louis
• Colin Kremitzki, Washington University School of Medicine in St. Louis
• Liya Yuan, Washington University School of Medicine in St. Louis
• Wendy Dong, Washington University School of Medicine in St. Louis
• Robi Mitra, Washington University School of Medicine in St. Louis
• Jeffrey Milbrandt, Washington University School of Medicine in St. Louis
• William Buchser, Washington University School of Medicine in St. Louis

Journal

npj Systems Biology and Applications

Publication Date

12-14-2025

Volume

12

Issue

1

First Page

3

Document Type

Open Access Publication

DOI

10.1038/s41540-025-00627-6

Rights and Permissions

Ali, L.M., Yim, A.K.Y., Gerbi, E. et al. Biophysical simulation enables segmentation and nervous system atlas mapping for image first spatial omics. npj Syst Biol Appl 12, 3 (2026). https://doi.org/10.1038/s41540-025-00627-6 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Ali, Lina Mohammed; Yim, Aldrin Kay Yuen; Gerbi, Emanuel; Nguyen, Thien; Tu, Nicholas; Ikede, Faith; Sampaleanu, Remi; Grigore, Diana; Waligorski, Jason; Kremitzki, Colin; Yuan, Liya; Dong, Wendy; Mitra, Robi; Milbrandt, Jeffrey; and Buchser, William, "Biophysical simulation enables segmentation and nervous system atlas mapping for image first spatial omics." npj Systems Biology and Applications. 12, 1. 3 (2025).
https://digitalcommons.wustl.edu/oa_4/6618

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.