A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies

Authors

• Fan He, Washington University School of Medicine in St. Louis
• Shuyang Lin, Washington University School of Medicine in St. Louis
• Bei Gao, Washington University School of Medicine in St. Louis
• Varun Ramesh, Washington University School of Medicine in St. Louis
• Alexander B Kim, Washington University School of Medicine in St. Louis
• Tim Kong, Washington University School of Medicine in St. Louis
• Daniel A C Fisher, Washington University School of Medicine in St. Louis
• Christopher T Letson, Washington University School of Medicine in St. Louis
• Molly Brakhane, Washington University School of Medicine in St. Louis
• Mary Fulbright, Washington University School of Medicine in St. Louis
• Yanbo Yu, Washington University School of Medicine in St. Louis
• Marco Sardiello, Washington University School of Medicine in St. Louis
• Jorge Di Paola, Washington University School of Medicine in St. Louis
• Stephen M Sykes, Washington University School of Medicine in St. Louis
• Stephen T Oh, Washington University School of Medicine in St. Louis

Journal

Cell communication and signaling

Publication Date

12-16-2025

Volume

24

Issue

1

First Page

61

Document Type

Open Access Publication

DOI

10.1186/s12964-025-02568-3

Rights and Permissions

He, F., Lin, S., Gao, B. et al. A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies. Cell Commun Signal 24, 61 (2026). https://doi.org/10.1186/s12964-025-02568-3 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

He, Fan; Lin, Shuyang; Gao, Bei; Ramesh, Varun; Kim, Alexander B; Kong, Tim; Fisher, Daniel A C; Letson, Christopher T; Brakhane, Molly; Fulbright, Mary; Yu, Yanbo; Sardiello, Marco; Di Paola, Jorge; Sykes, Stephen M; and Oh, Stephen T, "A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies." Cell communication and signaling. 24, 1. 61 (2025).
https://digitalcommons.wustl.edu/oa_4/6713

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.