Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice

Authors

• Erica V Ely, Washington University School of Medicine in St. Louis
• Kristin L Lenz, Washington University School of Medicine in St. Louis
• Sophie G Paradi, Washington University School of Medicine in St. Louis
• Seth Ack, Washington University School of Medicine in St. Louis
• Abraham Behrmann, Washington University School of Medicine in St. Louis
• Sarah Dunivan, Washington University School of Medicine in St. Louis
• Lauryn Braxton, Washington University School of Medicine in St. Louis
• Wolfgang Liedtke, Duke University
• Yong Chen, Duke University
• Kelsey H Collins, Washington University School of Medicine in St. Louis
• Farshid Guilak, Washington University School of Medicine in St. Louis

Journal

Arthritis research & therapy

Publication Date

7-19-2025

Volume

27

Issue

1

First Page

152

Document Type

Open Access Publication

DOI

10.1186/s13075-025-03620-w

Rights and Permissions

Ely, E.V., Lenz, K.L., Paradi, S.G. et al. Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice. Arthritis Res Ther 27, 152 (2025). https://doi.org/10.1186/s13075-025-03620-w This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Ely, Erica V; Lenz, Kristin L; Paradi, Sophie G; Ack, Seth; Behrmann, Abraham; Dunivan, Sarah; Braxton, Lauryn; Liedtke, Wolfgang; Chen, Yong; Collins, Kelsey H; and Guilak, Farshid, "Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice." Arthritis research & therapy. 27, 1. 152 (2025).
https://digitalcommons.wustl.edu/oa_4/6862

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.