Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease

Authors

• Phoebe Valdes, University of California, San Diego
• Andrew B Caldwell, University of California, San Diego
• Qing Liu, University of California, San Diego
• Michael Q Fitzgerald, University of California, San Diego
• Srinivasan Ramachandran, University of California, San Diego
• Celeste M Karch, Washington University School of Medicine in St. Louis
• Dominantly Inherited Alzheimer Network (DIAN)
• Douglas R Galasko, University of California, San Diego
• Shauna H Yuan, University of California, San Diego
• Steven L Wagner, University of California, San Diego
• Shankar Subramaniam, University of California, San Diego

Journal

Alzheimer's Research & Therapy

Publication Date

1-4-2025

Volume

17

Issue

1

First Page

5

Document Type

Open Access Publication

DOI

10.1186/s13195-024-01659-6

Rights and Permissions

Valdes, P., Caldwell, A.B., Liu, Q. et al. Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease. Alz Res Therapy 17, 5 (2025). https://doi.org/10.1186/s13195-024-01659-6 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Valdes, Phoebe; Caldwell, Andrew B; Liu, Qing; Fitzgerald, Michael Q; Ramachandran, Srinivasan; Karch, Celeste M; Dominantly Inherited Alzheimer Network (DIAN); Galasko, Douglas R; Yuan, Shauna H; Wagner, Steven L; and Subramaniam, Shankar, "Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease." Alzheimer's Research & Therapy. 17, 1. 5 (2025).
https://digitalcommons.wustl.edu/oa_4/6889

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.