Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury

Authors

• Hernán F Peñaloza, University of Pittsburgh
• Atish Gheware, Washington University School of Medicine in St. Louis
• Ananya Gupta, Washington University School of Medicine in St. Louis
• Donovan Watza, Washington University School of Medicine in St. Louis
• Anupam Kumari, Washington University School of Medicine in St. Louis
• Zeyu Xiong, Washington University School of Medicine in St. Louis
• Pooja Bhojraj, Washington University School of Medicine in St. Louis
• Jae-Sung Kim, Washington University School of Medicine in St. Louis
• Bo-Ram Jin, Washington University School of Medicine in St. Louis
• Kyunghee Choi, Washington University School of Medicine in St. Louis
• Matthew R Rosengart, Washington University School of Medicine in St. Louis
• Jaehyung Cho, Washington University School of Medicine in St. Louis
• Janet S Lee, Washington University School of Medicine in St. Louis
• et al.

Journal

Nature Communications

Publication Date

3-12-2026

Volume

17

Issue

1

First Page

3844

Document Type

Open Access Publication

DOI

10.1038/s41467-026-70489-x

Rights and Permissions

Peñaloza, H.F., Gheware, A., Gupta, A. et al. Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury. Nat Commun 17, 3844 (2026). https://doi.org/10.1038/s41467-026-70489-x This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Peñaloza, Hernán F; Gheware, Atish; Gupta, Ananya; Watza, Donovan; Kumari, Anupam; Xiong, Zeyu; Bhojraj, Pooja; Kim, Jae-Sung; Jin, Bo-Ram; Choi, Kyunghee; Rosengart, Matthew R; Cho, Jaehyung; Lee, Janet S; and et al., "Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury." Nature Communications. 17, 1. 3844 (2026).
https://digitalcommons.wustl.edu/oa_4/7138

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.