TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Authors

• Yan Xiong, Washington University School of Medicine in St. Louis
• Jaiprakash Sharma, Washington University School of Medicine in St. Louis
• Meggie N Young, Baylor College of Medicine
• Wen Xiong, Baylor College of Medicine
• Ali Jazayeri, Washington University School of Medicine in St. Louis
• Karl F Poncha, Baylor College of Medicine
• Ma Xenia G Ilagan, Washington University School of Medicine in St. Louis
• Qing Wang, Complete Omics Inc.
• Bei Gao, Washington University School of Medicine in St. Louis
• Hui Zheng, Baylor College of Medicine
• Nicolas L Young, Baylor College of Medicine
• Marco Sardiello, Washington University School of Medicine in St. Louis

Journal

Nature Communications

Publication Date

4-1-2026

Volume

17

Issue

1

First Page

4679

Document Type

Open Access Publication

DOI

10.1038/s41467-026-71001-1

Rights and Permissions

Xiong, Y., Sharma, J., Young, M.N. et al. TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade. Nat Commun 17, 4679 (2026). https://doi.org/10.1038/s41467-026-71001-1 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Xiong, Yan; Sharma, Jaiprakash; Young, Meggie N; Xiong, Wen; Jazayeri, Ali; Poncha, Karl F; Ilagan, Ma Xenia G; Wang, Qing; Gao, Bei; Zheng, Hui; Young, Nicolas L; and Sardiello, Marco, "TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade." Nature Communications. 17, 1. 4679 (2026).
https://digitalcommons.wustl.edu/oa_4/7144

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.