BACH2 regulates T cell lineage state to enhance CAR T cell function

Authors

• Tien-Ching Chang, Washington University School of Medicine in St. Louis
• Amanda Heard, Washington University School of Medicine in St. Louis
• John Lattin, Washington University School of Medicine in St. Louis
• John M Warrington, Washington University School of Medicine in St. Louis
• Amanda Barrett, Washington University School of Medicine in St. Louis
• Jack H Landmann, Washington University School of Medicine in St. Louis
• Yangdon Tenzin, Washington University School of Medicine in St. Louis
• Vishaal Ganesh, Washington University School of Medicine in St. Louis
• Bryant Thompson, Washington University School of Medicine in St. Louis
• Sadia Afrin, Washington University School of Medicine in St. Louis
• Deepesh Kumar Gupta, Washington University School of Medicine in St. Louis
• Ju-Fang Chang, Washington University School of Medicine in St. Louis
• Julie Ritchey, Washington University School of Medicine in St. Louis
• Mehmet Emrah Selli, Washington University School of Medicine in St. Louis
• Yu-Sung Hsu, Washington University School of Medicine in St. Louis
• A J Federico, Washington University School of Medicine in St. Louis
• Avery Horn, Washington University School of Medicine in St. Louis
• Michael P Meers, Washington University School of Medicine in St. Louis
• John F DiPersio, Washington University School of Medicine in St. Louis
• Nathan Singh, Washington University School of Medicine in St. Louis
• et al.

Journal

Nature Immunology

Publication Date

3-1-2026

Volume

27

Issue

3

First Page

413

Last Page

424

Document Type

Open Access Publication

DOI

10.1038/s41590-025-02391-5

Rights and Permissions

Chang, TC., Heard, A., Lattin, J. et al. BACH2 regulates T cell lineage state to enhance CAR T cell function. Nat Immunol 27, 413–424 (2026). https://doi.org/10.1038/s41590-025-02391-5 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Recommended Citation

Chang, Tien-Ching; Heard, Amanda; Lattin, John; Warrington, John M; Barrett, Amanda; Landmann, Jack H; Tenzin, Yangdon; Ganesh, Vishaal; Thompson, Bryant; Afrin, Sadia; Gupta, Deepesh Kumar; Chang, Ju-Fang; Ritchey, Julie; Selli, Mehmet Emrah; Hsu, Yu-Sung; Federico, A J; Horn, Avery; Meers, Michael P; DiPersio, John F; Singh, Nathan; and et al., "BACH2 regulates T cell lineage state to enhance CAR T cell function." Nature Immunology. 27, 3. 413 - 424. (2026).
https://digitalcommons.wustl.edu/oa_4/7167

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.