Loss of Nemp1 disrupts female meiosis and activates a conserved ATM-CHK2 checkpoint

Authors

• Bilal Ahmad Hakim, Washington University School of Medicine in St. Louis
• Yonit Tsatskis, The Hospital for Sick Children, Toronto
• Ling Zhang, Washington University School of Medicine in St. Louis
• Esther Choi, University of Pittsburgh
• Ying Zhang, Lunenfeld Tanenbaum Research Institute
• Didier Hodzic, Washington University School of Medicine in St. Louis
• Que Wu, Lunenfeld Tanenbaum Research Institute
• MuYun Zhang, Lunenfeld Tanenbaum Research Institute
• Maryam Pashaei, University of Toronto
• Kyungwon Ha, University of Toronto
• Jannette Rusch, Washington University School of Medicine in St. Louis
• Julie A Brill, University of Toronto
• Miguel Angel Brieño-Enríquez, University of Pittsburgh
• Andrea Jurisicova, University of Toronto
• Helen McNeill, Washington University School of Medicine in St. Louis

Journal

Nature Communications

Publication Date

7-24-2026

Volume

17

Issue

1

First Page

9100

Document Type

Open Access Publication

DOI

10.1038/s41467-026-75874-0

Rights and Permissions

Hakim, B.A., Tsatskis, Y., Zhang, L. et al. Loss of Nemp1 disrupts female meiosis and activates a conserved ATM-CHK2 checkpoint. Nat Commun 17, 9100 (2026). https://doi.org/10.1038/s41467-026-75874-0 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Hakim, Bilal Ahmad; Tsatskis, Yonit; Zhang, Ling; Choi, Esther; Zhang, Ying; Hodzic, Didier; Wu, Que; Zhang, MuYun; Pashaei, Maryam; Ha, Kyungwon; Rusch, Jannette; Brill, Julie A; Brieño-Enríquez, Miguel Angel; Jurisicova, Andrea; and McNeill, Helen, "Loss of Nemp1 disrupts female meiosis and activates a conserved ATM-CHK2 checkpoint." Nature Communications. 17, 1. 9100 (2026).
https://digitalcommons.wustl.edu/oa_4/7258

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.