APOE-stratified proteomic and metabolomic analysis reveals mitochondrial dysfunction inflammation and lipid dysregulation in Alzheimer's disease

Authors

• Fuhai Li, Washington University School of Medicine in St. Louis
• Yike Chen, Washington University School of Medicine in St. Louis
• Daniel Western, Washington University School of Medicine in St. Louis
• Muhammad Ali, Washington University School of Medicine in St. Louis
• Menghan Liu, Washington University School of Medicine in St. Louis
• Katherine Gong, Washington University School of Medicine in St. Louis
• Ying Xu, Washington University School of Medicine in St. Louis
• Joseph Lowery, Washington University School of Medicine in St. Louis
• David M Holtzman, Washington University School of Medicine in St. Louis
• Carlos Cruchaga, Washington University School of Medicine in St. Louis
• et al.

Journal

Advanced Science

Publication Date

4-1-2026

Volume

13

Issue

21

First Page

e13872

Document Type

Open Access Publication

DOI

10.1002/advs.202513872

Rights and Permissions

Li F, Chen Y, Western D, Ali M, Liu M, Gong K, Xu Y, Lowery J, Holtzman DM, Robins C, Eicher JD, Huang YN, Liu S, Park T, Saykin AJ, Nho K, Moqri M, Mohs RC, Farinas A, Moran-Losada P, Oh HS, Wyss-Coray T, Cruchaga C. APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease. Adv Sci (Weinh). 2026 Apr;13(21):e13872. doi: 10.1002/advs.202513872. © 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Recommended Citation

Li, Fuhai; Chen, Yike; Western, Daniel; Ali, Muhammad; Liu, Menghan; Gong, Katherine; Xu, Ying; Lowery, Joseph; Holtzman, David M; Cruchaga, Carlos; and et al., "APOE-stratified proteomic and metabolomic analysis reveals mitochondrial dysfunction inflammation and lipid dysregulation in Alzheimer's disease." Advanced Science. 13, 21. e13872 (2026).
https://digitalcommons.wustl.edu/oa_4/7263

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.