Ketone body supplementation exerts renoprotective effects against adenine-induced kidney injury via OXCT1-mediated ketolysis in mice

Authors

• Shoji Omachi, Shiga University of Medical Science
• Sho Sugahara, Shiga University of Medical Science
• Junya Horiguchi, Shiga University of Medical Science
• Mako Yasuda-Yamahara, Shiga University of Medical Science
• Shogo Kuwagata, Shiga University of Medical Science
• Kosuke Yamahara, Shiga University of Medical Science
• Yuki Tanaka-Sasaki, Shiga University of Medical Science
• Shogo Ida, Shiga University of Medical Science
• Tetsuro Kusaba, Kyoto Prefectural University of Medicine
• Benjamin D Humphreys, Washington University School of Medicine in St. Louis
• Kenji Kufukihara, Keio University
• Jin Nakahara, Keio University
• Masami Chin-Kanasaki, Shiga University of Medical Science
• Shinji Kume, Shiga University of Medical Science

Journal

FASEB journal

Publication Date

3-31-2026

Volume

40

Issue

6

First Page

e71650

Document Type

Open Access Publication

DOI

10.1096/fj.202503908R

Rights and Permissions

Omachi S, Sugahara S, Horiguchi J, Yasuda-Yamahara M, Kuwagata S, Yamahara K, Tanaka-Sasaki Y, Ida S, Kusaba T, Humphreys BD, Kufukihara K, Nakahara J, Chin-Kanasaki M, Kume S. Ketone Body Supplementation Exerts Renoprotective Effects Against Adenine-Induced Kidney Injury via OXCT1-Mediated Ketolysis in Mice. FASEB J. 2026 Mar 31;40(6):e71650. doi: 10.1096/fj.202503908R. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.© 2026 The Author(s). The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.

Recommended Citation

Omachi, Shoji; Sugahara, Sho; Horiguchi, Junya; Yasuda-Yamahara, Mako; Kuwagata, Shogo; Yamahara, Kosuke; Tanaka-Sasaki, Yuki; Ida, Shogo; Kusaba, Tetsuro; Humphreys, Benjamin D; Kufukihara, Kenji; Nakahara, Jin; Chin-Kanasaki, Masami; and Kume, Shinji, "Ketone body supplementation exerts renoprotective effects against adenine-induced kidney injury via OXCT1-mediated ketolysis in mice." FASEB journal. 40, 6. e71650 (2026).
https://digitalcommons.wustl.edu/oa_4/7265

Department

ICTS (Institute of Clinical and Translational Sciences)