Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Authors

• Gabriella A Perez, Baylor College of Medicine
• Zoe Lai, Washington University School of Medicine in St. Louis
• George A Edwards Iii, Baylor College of Medicine
• Jacob M Dundee, Washington University School of Medicine in St. Louis
• Shannon N Leahy, Washington University School of Medicine in St. Louis
• Chuangye Qi, Baylor College of Medicine
• Yanyan Qi, Baylor College of Medicine
• Ye-Jin Park, Baylor College of Medicine
• Tzu-Chiao Lu, Baylor College of Medicine
• M Danish Uddin, Baylor College of Medicine
• Rong Zhao, Baylor College of Medicine
• Hui Zheng, Baylor College of Medicine
• Hongjie Li, Baylor College of Medicine
• Joanna L Jankowsky, Washington University School of Medicine in St. Louis

Journal

Molecular Neurodegeneration

Publication Date

1-6-2026

Volume

21

Issue

1

First Page

2

Document Type

Open Access Publication

DOI

10.1186/s13024-025-00919-9

Rights and Permissions

Perez, G.A., Lai, Z., Edwards III, G.A. et al. Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models. Mol Neurodegeneration 21, 2 (2026). https://doi.org/10.1186/s13024-025-00919-9 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Recommended Citation

Perez, Gabriella A; Lai, Zoe; Edwards Iii, George A; Dundee, Jacob M; Leahy, Shannon N; Qi, Chuangye; Qi, Yanyan; Park, Ye-Jin; Lu, Tzu-Chiao; Uddin, M Danish; Zhao, Rong; Zheng, Hui; Li, Hongjie; and Jankowsky, Joanna L, "Neuronal subtype governs amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models." Molecular Neurodegeneration. 21, 1. 2 (2026).
https://digitalcommons.wustl.edu/oa_4/7330

Additional Links

Supplemental material is available for this article at publisher site.